Liddie Shervin, Goody Robin J, Valles Rodrigo, Lawrence Matthew S
St. Kitts Biomedical Research Foundation, St. Kitts, West Indies.
J Med Primatol. 2010 Dec;39(6):389-98. doi: 10.1111/j.1600-0684.2010.00422.x.
Hematology and clinical chemistry (HCC) reference values are critical in veterinary practice and in vivo pre-clinical research, enabling detection of health abnormalities, response to therapeutic intervention or adverse toxicological effects, as well as monitoring of clinical management.
In this report, reference ranges for 46 HCC parameters were characterized in 331 wild-caught and colony-bred African green monkeys. Effects of sex, weight and duration of captivity were determined by one-way analysis of variance.
Significant sex differences were observed for several HCC parameters. Significant differences were also observed for select HCC variables between newly caught animals and those held in captivity for 1-12 months or longer.
Comparison of this data with other non-human primate species and humans highlights similarities and disparities between species. Potential causes of interpopulation variability and relevance to the use of the African green monkey as a non-human primate model are discussed.
血液学和临床化学（HCC）参考值在兽医实践和体内临床前研究中至关重要，有助于检测健康异常情况、对治疗干预或不良毒理学效应的反应，以及监测临床管理情况。
在本报告中，对331只野生捕获和圈养繁殖的非洲绿猴的46项HCC参数的参考范围进行了表征。通过单因素方差分析确定性别、体重和圈养时间的影响。
观察到几个HCC参数存在显著的性别差异。在新捕获的动物与圈养1至12个月或更长时间的动物之间，某些HCC变量也观察到显著差异。
将这些数据与其他非人类灵长类物种和人类进行比较，突出了物种之间的异同。讨论了种群间变异性的潜在原因以及与将非洲绿猴用作非人类灵长类动物模型的相关性。
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