Institut für Anatomie I: Zelluläre Neurobiologie, Hamburg, Germany.
Eur J Neurosci. 2010 May;31(9):1511-8. doi: 10.1111/j.1460-9568.2010.07222.x.
Reelin signalling in the early developing cortex regulates radial migration of cortical neurons. Later in development, Reelin promotes maturation of dendrites and dendritic spines. Finally, in the mature brain, it is involved in modulating synaptic function. In recent years, efforts to identify downstream signalling events induced by binding of Reelin to lipoprotein receptors led to the characterization of novel components of the Reelin signalling cascade. In the present review, we first address distinct functions of the Reelin receptors Apoer2 and Vldlr in cortical layer formation, followed by a discussion on the recently identified downstream effector molecule n-cofilin, involved in regulating actin cytoskeletal dynamics required for coordinated neuronal migration. Next, we discuss possible functions of the recently identified Reelin-Notch signalling crosstalk, and new aspects of the role of Reelin in the formation of the dentate radial glial scaffold. Finally, progress in characterizing the function of Reelin in modulating synaptic function in the adult brain is summarized. The present review has been inspired by a session entitled 'Functions of Reelin in the developing and adult hippocampus', held at the Spring Hippocampal Research Conference in Verona/Italy, June 2009.
Reelin 信号在早期发育皮层中调节皮质神经元的放射状迁移。在发育后期，Reelin 促进树突和树突棘的成熟。最后，在成熟的大脑中，它参与调节突触功能。近年来，人们努力识别 Reelin 与脂蛋白受体结合所诱导的下游信号事件，导致了 Reelin 信号级联的新成分的鉴定。在本综述中，我们首先讨论了 Reelin 受体 Apoer2 和 Vldlr 在皮质层形成中的不同功能，然后讨论了最近鉴定的下游效应分子 n-cofilin，它参与调节协调神经元迁移所需的肌动蛋白细胞骨架动力学。接下来，我们讨论了最近发现的 Reelin-Notch 信号串扰的可能功能，以及 Reelin 在形成齿状辐射状胶质支架中的作用的新方面。最后，总结了描述 Reelin 在调节成年大脑中突触功能方面的功能的进展。本综述受到了在意大利维罗纳举行的 2009 年春季海马研究会议上题为“Reelin 在发育中和成年海马中的功能”的会议的启发。
