Department of Pediatrics, Milton S, Hershey Medical Center, Hershey, PA.
Allergy Asthma Clin Immunol. 2008 Dec 15;4(4):164-71. doi: 10.1186/1710-1492-4-4-164.
: Work-related asthma is asthma that is caused or exacerbated by exposures at work. It is the most common form of occupational lung disease in developed countries. It has important impacts on the health and well-being of the affected individual, as well as consequences for society because of unemployment issues and workers' compensation claims. With ongoing exposure, occupational asthma can result in persistent airway hyperresponsiveness and, possibly, permanent disability for the individual. Thus, it is important for the clinician to be able to diagnose this disorder as quickly and accurately as possible. The evaluation of a patient with work-related asthma can be extensive. It includes obtaining a consistent history, identifying the cause in the workplace, and confirming the diagnosis with objective tests. After a diagnosis has been made, treatment must sometimes go beyond the medications used for nonoccupational asthma and include interventions to minimize or completely remove the individual from exposure to the causal agent if he or she has sensitizer-induced occupational asthma. In addition, once an individual has been identified with occupational asthma, steps should be taken to prevent the development of this disorder in other workers. The purpose of this article is to review the current literature and provide the clinician with a stepwise approach to the diagnosis and management of a patient with work-related asthma.
职业性哮喘是由工作场所暴露引起或加重的哮喘。它是在发达国家最常见的职业性肺部疾病。它对受影响个体的健康和福祉,以及由于失业问题和工人赔偿要求对社会造成的后果都有重要影响。随着持续暴露,职业性哮喘可能导致个体持续气道高反应性,并可能导致永久性残疾。因此,临床医生尽快准确地诊断这种疾病非常重要。职业性哮喘患者的评估可能非常广泛。它包括获取一致的病史,确定工作场所中的原因,并通过客观测试确认诊断。诊断后,如果患者患有致敏原引起的职业性哮喘,治疗有时必须超出非职业性哮喘使用的药物,并包括采取干预措施,将个体最小化或完全从接触致病因子中去除。此外,一旦个体被确定患有职业性哮喘,就应采取措施防止其他工人患上这种疾病。本文的目的是回顾当前的文献,并为临床医生提供诊断和管理职业性哮喘患者的逐步方法。