Møller Frederik Trier, Andersen Stig Ejdrup
Klinisk Farmakologisk Afdeling, Bispebjerg Hospital, 2400 København NV, Denmark.
Ugeskr Laeger. 2010 May 24;172(21):1602-6.
The aim was to describe the prescription patterns of benzodiazepines (BZD) and cyclopyrrolones (Z-drugs) in a population of medical and surgical patients prior to, during and after hospital admission.
Data were collected from medical records, the physicians' order entry system and the national electronic pharmacy registry.
Overall, 38% of the 135 included patients did not receive BZD/Z-drugs at any time. A total of 30% were pre-admission users. While in hospital, 50% were users and 17% were users at discharge and 30% during the six months follow-up period (p < 0.0001). Changes in the usage pattern were mainly due to a significant increase in Z-drug use during hospital admission combined with a decrease in BZD and Z-drug use at discharge. During hospitalisation, 40% of the 94 pre-admission non-users of BZD/Z-drugs received BZD/Z-drugs. At the time of discharge, 61% of pre-admission users had become non-users, and 8.5% of the non-users had become users. Over the 6-month post-discharge period, 29 patients (21%) received >or= 3 prescriptions for BZD/Z-drugs (chronic users) compared with 21 (16%) before admission.
Medical and surgical hospitalized patients are frequently treated with Z-drugs and BZDs prior to, during and after hospital admission. The usage pattern changes significantly during hospital admission, with more prescriptions for Z-drugs being issued.
目的是描述苯二氮䓬类药物（BZD）和环吡咯酮类药物（Z 类药物）在医疗和外科患者群体入院前、住院期间及出院后的处方模式。
数据收集自病历、医生医嘱录入系统及国家电子药房登记处。
总体而言，135 例纳入患者中，38%在任何时候都未接受 BZD/Z 类药物治疗。共有 30%为入院前使用者。住院期间，50%为使用者，出院时 17%为使用者，六个月随访期内 30%为使用者（p < 0.0001）。使用模式的变化主要是由于住院期间 Z 类药物使用显著增加，同时出院时 BZD 和 Z 类药物使用减少。住院期间，94 例入院前未使用 BZD/Z 类药物的患者中有 40%接受了 BZD/Z 类药物治疗。出院时，入院前使用者中有 61%不再使用，未使用者中有 8.5%开始使用。出院后 6 个月期间，29 例患者（21%）接受了≥3 张 BZD/Z 类药物处方（长期使用者），而入院前为 21 例（16%）。
医疗和外科住院患者在入院前、住院期间及出院后经常接受 Z 类药物和 BZDs 治疗。住院期间使用模式有显著变化，Z 类药物处方增加。
