近交系小鼠对听源性惊厥易感性的遗传剖析。
Genetic dissection of susceptibility to audiogenic seizures in inbred mice.
作者信息
Neumann P E, Collins R L
机构信息
Department of Neurology, Children's Hospital, Boston, MA.
出版信息
Proc Natl Acad Sci U S A. 1991 Jun 15;88(12):5408-12. doi: 10.1073/pnas.88.12.5408.
Abstract
Mice of some inbred strains, such as 21-day-old DBA/2J mice, have generalized convulsions when exposed to intense auditory stimulation. Analysis of susceptibility to audiogenic seizures in BXD recombinant inbred strains has demonstrated the influence of at least three loci. One locus, Asp-1, is located on chromosome 12 between Ah and D12Nyu1; another locus, Asp-2, is on chromosome 4, tightly linked to b. Here we report evidence that Asp-2 is located within an 8-centimorgan segment distal to b and that Asp-3 is linked to Mtv-1 on chromosome 7. We also present evidence that these three loci account for most of the heritable variation in susceptibility to audiogenic seizures in crosses of DBA/2J and C57BL/6J mice and that susceptibility to audiogenic seizures is influenced by genomic imprinting. Thus, genomic imprinting may complicate linkage and mapping studies and should be considered in analyses of complex modes of inheritance.
摘要
一些近交系小鼠，如21日龄的DBA/2J小鼠，在受到强烈听觉刺激时会发生全身性惊厥。对BXD重组近交系小鼠听源性癫痫易感性的分析表明，至少有三个基因座起作用。一个基因座Asp-1位于12号染色体上Ah和D12Nyu1之间；另一个基因座Asp-2位于4号染色体上，与b紧密连锁。在此我们报告证据表明，Asp-2位于b远端的一个8厘摩区域内，且Asp-3与7号染色体上的Mtv-1连锁。我们还提供证据表明，在DBA/2J和C57BL/6J小鼠杂交中，这三个基因座解释了听源性癫痫易感性的大部分遗传变异，且听源性癫痫易感性受基因组印记影响。因此，基因组印记可能会使连锁和定位研究复杂化，在复杂遗传模式分析中应予以考虑。
相似文献
1
Genetic dissection of susceptibility to audiogenic seizures in inbred mice.近交系小鼠对听源性惊厥易感性的遗传剖析。
Proc Natl Acad Sci U S A. 1991 Jun 15;88(12):5408-12. doi: 10.1073/pnas.88.12.5408.
2
Mapping of two genes that influence susceptibility to audiogenic seizures in crosses of C57BL/6J and DBA/2J mice.在C57BL/6J和DBA/2J小鼠杂交实验中，对两个影响听源性癫痫易感性的基因进行定位。
Behav Genet. 1990 Mar;20(2):307-23. doi: 10.1007/BF01067798.
3
Confirmation of the influence of a chromosome 7 locus on susceptibility to audiogenic seizures.
Mamm Genome. 1992;3(5):250-3. doi: 10.1007/BF00292152.
4
Audiogenic seizure proneness requires the contribution of two susceptibility loci in mice.听觉激发性癫痫易感性需要两个易感基因座在小鼠中的贡献。
Neurogenetics. 2011 Aug;12(3):253-7. doi: 10.1007/s10048-011-0289-2. Epub 2011 Jun 18.
5
Genetic analysis of audiogenic seizure susceptibility in C57BL/6J X DBA/2J recombinant inbred strains of mice.C57BL/6J与DBA/2J小鼠重组近交系中听源性癫痫易感性的遗传分析。
Genetics. 1980 Mar;94(3):701-18. doi: 10.1093/genetics/94.3.701.
6
Genomic imprinting and audiogenic seizures in mice.小鼠的基因组印记与听源性癫痫发作
Behav Genet. 1997 Sep;27(5):465-75. doi: 10.1023/a:1025626501148.
7
8
Genetic mapping of a locus (mass1) causing audiogenic seizures in mice.导致小鼠听源性癫痫发作的一个基因座（mass1）的遗传图谱。
Genomics. 1998 Apr 15;49(2):188-92. doi: 10.1006/geno.1998.5229.
9
Febrile convulsions in inbred strains of mice susceptible and resistant to audiogenic seizures.对听源性癫痫发作敏感和耐受的近交系小鼠中的热性惊厥
Epilepsia. 1980 Dec;21(6):637-45. doi: 10.1111/j.1528-1157.1980.tb04317.x.
10
Brain adrenoceptor binding sites in mice susceptible (DBA/2J) and resistant (C57 Bl/6) to audiogenic seizures.对听源性癫痫敏感（DBA/2J）和抗性（C57 Bl/6）的小鼠大脑肾上腺素能受体结合位点。
J Neurochem. 1986 Jul;47(1):173-7. doi: 10.1111/j.1471-4159.1986.tb02846.x.
引用本文的文献
1
Excitatory neuron-specific suppression of the integrated stress response contributes to autism-related phenotypes in fragile X syndrome.脆性 X 综合征相关自闭症表型与兴奋性神经元特异性抑制整体应激反应有关。
Neuron. 2023 Oct 4;111(19):3028-3040.e6. doi: 10.1016/j.neuron.2023.06.017. Epub 2023 Jul 19.
2
Differential Expression of Hypertensive Phenotypes in BXD Mouse Strains in Response to Angiotensin II.BXD 小鼠品系对血管紧张素Ⅱ反应的高血压表型差异表达。
Am J Hypertens. 2017 Dec 8;31(1):108-114. doi: 10.1093/ajh/hpx144.
3
Magnetic Resonance Monitoring of Disease Progression in mdx Mice on Different Genetic Backgrounds.不同遗传背景下mdx小鼠疾病进展的磁共振监测
Am J Pathol. 2017 Sep;187(9):2060-2070. doi: 10.1016/j.ajpath.2017.05.010.
4
Multidimensional Genetic Analysis of Repeated Seizures in the Hybrid Mouse Diversity Panel Reveals a Novel Epileptogenesis Susceptibility Locus.杂交小鼠多样性面板中反复癫痫发作的多维遗传分析揭示了一个新的癫痫发生易感位点。
G3 (Bethesda). 2017 Aug 7;7(8):2545-2558. doi: 10.1534/g3.117.042234.
5
A Murine Hypertrophic Cardiomyopathy Model: The DBA/2J Strain.一种小鼠肥厚型心肌病模型：DBA/2J品系。
PLoS One. 2015 Aug 4;10(8):e0133132. doi: 10.1371/journal.pone.0133132. eCollection 2015.
6
A locus on mouse Ch10 influences susceptibility to limbic seizure severity: fine mapping and in silico candidate gene analysis.小鼠 Ch10 上的一个基因座影响边缘性癫痫发作严重程度的易感性：精细定位和计算机候选基因分析。
Genes Brain Behav. 2014 Mar;13(3):341-9. doi: 10.1111/gbb.12116. Epub 2014 Jan 27.
7
Soy-based diet exacerbates seizures in mouse models of neurological disease.基于大豆的饮食会加重神经疾病小鼠模型中的癫痫发作。
J Alzheimers Dis. 2013;33(3):797-805. doi: 10.3233/JAD-2012-121426.
8
Networks modulating the retinal response to injury: insights from microarrays, expression genetics, and bioinformatics.调节视网膜对损伤反应的网络：来自微阵列、表达遗传学和生物信息学的见解。
Adv Exp Med Biol. 2012;723:649-56. doi: 10.1007/978-1-4614-0631-0_82.
9
Mapping a mouse limbic seizure susceptibility locus on chromosome 10.定位 10 号染色体上的小鼠边缘性癫痫易感性基因座。
Epilepsia. 2011 Nov;52(11):2076-83. doi: 10.1111/j.1528-1167.2011.03256.x. Epub 2011 Sep 11.
10
Audiogenic seizure proneness requires the contribution of two susceptibility loci in mice.听觉激发性癫痫易感性需要两个易感基因座在小鼠中的贡献。
Neurogenetics. 2011 Aug;12(3):253-7. doi: 10.1007/s10048-011-0289-2. Epub 2011 Jun 18.
本文引用的文献
1
Inheritance of audiogenic seizure susceptibility in the mouse.小鼠听源性癫痫易感性的遗传
Genetics. 1950 Nov;35(6):622-32. doi: 10.1093/genetics/35.6.622.
2
Genetic analysis of audiogenic seizure susceptibility in C57BL/6J X DBA/2J recombinant inbred strains of mice.C57BL/6J与DBA/2J小鼠重组近交系中听源性癫痫易感性的遗传分析。
Genetics. 1980 Mar;94(3):701-18. doi: 10.1093/genetics/94.3.701.
3
Genetic analysis of protein variations in Mus musculus using two-dimensional electrophoresis.利用二维电泳对小家鼠蛋白质变异进行遗传分析。
Biochem Genet. 1980 Feb;18(1-2):185-97. doi: 10.1007/BF00504368.
4
Genetic linkage between the AH locus and a major gene that inhibits susceptibility to audiogenic seizures in mice.AH基因座与一个抑制小鼠对听源性癫痫易感性的主基因之间的遗传连锁。
Genetics. 1981 Sep;99(1):117-26. doi: 10.1093/genetics/99.1.117.
5
Genetic heterogeneity for the development of audiogenic seizures in mice.小鼠听源性癫痫发作发展的遗传异质性。
Brain Res. 1983 Jul 25;271(2):325-9. doi: 10.1016/0006-8993(83)90294-9.
6
Genetic mapping of endogenous mouse mammary tumor viruses: locus characterization, segregation, and chromosomal distribution.内源性小鼠乳腺肿瘤病毒的基因定位：基因座特征、分离及染色体分布
J Virol. 1981 Dec;40(3):735-44. doi: 10.1128/JVI.40.3.735-744.1981.
7
Genetic association between Ca2+-ATPase activity and audiogenic seizures in mice.
J Neurochem. 1984 Jun;42(6):1771-4. doi: 10.1111/j.1471-4159.1984.tb12771.x.
8
Audiogenic seizure susceptibility induced in C57BL-6J mice by prior auditory exposure.先前的听觉暴露诱导C57BL - 6J小鼠产生对声音诱发癫痫的易感性。
Science. 1967 Nov 17;158(3803):938-40. doi: 10.1126/science.158.3803.938-a.
9
Audiogenic seizures in eleven mouse strains.
J Hered. 1967 May-Jun;58(3):135-40. doi: 10.1093/oxfordjournals.jhered.a107565.
10
The genetics of sound induced seizure in inbred mice.近交系小鼠声音诱发癫痫的遗传学研究
Genetics. 1966 Jul;54(1):95-103. doi: 10.1093/genetics/54.1.95.
Zotero 插件