一种将酮肟转化为相应羰基化合物的便捷还原方法。
An expedient reductive method for conversion of ketoximes to the corresponding carbonyl compounds.
作者信息
Majireck Max M, Witek Jason A, Weinreb Steven M
机构信息
Department of Chemistry, The Pennsylvania State University, University Park, Pennsylania 16802 USA.
出版信息
Tetrahedron Lett. 2010 Jul 1;51(27):3555-3557. doi: 10.1016/j.tetlet.2010.04.131.
Abstract
A wide array of readily prepared pivalates of ketoximes can be converted to the corresponding ketones in good yields by treatment with iron powder in THF containing catalytic amounts of both trimethylsilyl chloride and glacial acetic acid at room temperature for 30 minutes, followed by a brief aqueous workup.
摘要
通过在含有催化量的三甲基氯硅烷和冰醋酸的四氢呋喃中，于室温下用铁粉处理30分钟，随后进行简短的水相后处理，一系列易于制备的酮肟新戊酸酯能够以良好的产率转化为相应的酮。
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