Department of Dermatology, University of Florence, IT-50121 Firenze, Italy.
Acta Derm Venereol. 2010 May;90(3):283-6. doi: 10.2340/00015555-0841.
With the improvement in survival after breast cancer there has been increasing interest in the long-term effects of radiotherapy, including the development of tumours. Compared with the general population, breast cancer survivors have a 10-50% higher risk of developing a second cancer. Radiotherapy may play a role in the onset of such lesions. We describe here the case of a 68-year-old woman who developed synchronous cutaneous angiosarcoma, melanoma and morphea of the breast skin and the local area, 14 years after radiotherapy for breast carcinoma. Given the risk of post-radiation secondary primaries in breast cancer patients, long-term surveillance is necessary, with particular attention being paid to skin changes in the irradiation field. Radiation-induced morphea is a rare complication in which immunological abnormalities may stimulate malignant transformation. Long-term studies are required to clarify the pathogenesis of these rare associations.
随着乳腺癌患者生存率的提高，人们对放疗的长期影响（包括肿瘤的发生）越来越感兴趣。与一般人群相比，乳腺癌幸存者发生第二原发癌的风险增加了 10-50%。放疗可能在这些病变的发生中起作用。我们在这里描述了一位 68 岁女性的病例，她在 14 年前因乳腺癌接受放疗后，同时发生了乳房皮肤和局部的皮肤血管肉瘤、黑色素瘤和硬皮病。鉴于乳腺癌患者放疗后发生继发性第二原发癌的风险，需要进行长期监测，特别要注意照射野的皮肤变化。放射性硬皮病是一种罕见的并发症，其中免疫异常可能刺激恶性转化。需要进行长期研究以阐明这些罕见关联的发病机制。
