AML, Department of Engineering Mechanics, Tsinghua University, Beijing, China.
Biomech Model Mechanobiol. 2011 Apr;10(2):221-7. doi: 10.1007/s10237-010-0228-4. Epub 2010 Jun 5.
It was reported that a single-strand DNA (ssDNA) could be inbreathed spontaneously into a carbon nanotube (CNT). In this work, the complementary process, i.e. pulling a piece of ssDNA out of a single-walled (SW) CNT, is simulated using molecular dynamic methods. The pulling force is found to fluctuate around a plateau of 250 pN with the base types identifiable by the varying amplitudes. One may thus numerate the bases in DNA by counting the fluctuation repetition or detect the information of DNA sequence by considering the fluctuating amplitudes.
据报道，单链 DNA（ssDNA）可以自发地吸入到碳纳米管（CNT）中。在这项工作中，使用分子动力学方法模拟了互补过程，即从单壁（SW）碳纳米管中拉出一段 ssDNA。发现拉力在 250 pN 的平台附近波动，碱基类型可以通过变化的幅度来识别。因此，可以通过计算波动重复次数来对 DNA 中的碱基进行编号，或者通过考虑波动幅度来检测 DNA 序列的信息。
