Department of Immunology and Gnotobiology, Institute of Microbiology, v.v.i., Academy of Sciences of the Czech Republic, 549 22, Nový Hrádek, Czech Republic.
Folia Microbiol (Praha). 2010 May;55(3):295-300. doi: 10.1007/s12223-010-0044-3. Epub 2010 Jun 6.
Innate immunity is shaped by a complex of redundant and pleiotropic factors that ensure recognition, alert and suppression of pathogens. Innate immune responses in the gut are complicated by the requirement of parallel tolerance to commensal microflora predominating in cell numbers and species. In normal individuals, the intestinal mucosa together with relevant lymph nodes represents a robust barrier against systemic spread of non-typhoid Salmonella. Contemporary insights into these defense mechanisms are reviewed.
先天免疫是由复杂的冗余和多效因子形成的，这些因子可确保对病原体的识别、警戒和抑制。肠道中的先天免疫反应因需要对占细胞数量和种类优势的共生微生物群落保持平行耐受而变得复杂。在正常个体中，肠黏膜与相关的淋巴结一起，是防止非伤寒沙门氏菌全身扩散的强大屏障。本文综述了对这些防御机制的最新认识。
