Saeed M, Wendland M F, Masui T, Connolly A J, Derugin N, Brasch R C, Higgins C B
Department of Radiology, University of California, San Francisco 94143.
Radiology. 1991 Jul;180(1):153-60. doi: 10.1148/radiology.180.1.2052685.
The effect of a new intravascular magnetic resonance (MR) contrast medium (gadolinium diethylenetriaminepentaacetic acid [DTPA] polylysine) was evaluated in acute, subacute, and chronic myocardial infarctions in rats. Signal intensity (SI) was measured before and after intravenous administration of Gd-DTPA polylysine. Before administration of contrast material, chronic infarctions had lower SI than normal myocardium. With Gd-DTPA polylysine, three zones were identified in acute and subacute stages of myocardial infarction, but in the chronic stage, images demonstrated two zones. In acute and subacute infarctions, Gd-DTPA polylysine produced greater enhancement (over 60 minutes) in the peri-infarction zone than in the normal or infarcted myocardium. In chronic infarctions, Gd-DTPA polylysine had no discernible effect on the SI of the central infarction zone. Overall, it caused no significant hemodynamic effects. MR imaging with Gd-DTPA polylysine produced differential tissue enhancement in myocardial infarctions, which varied according to the age of the infarction.
在大鼠急性、亚急性和慢性心肌梗死中评估了一种新型血管内磁共振（MR）造影剂（钆二乙烯三胺五乙酸[DTPA]多聚赖氨酸）的效果。在静脉注射钆-DTPA多聚赖氨酸前后测量信号强度（SI）。在注射造影剂之前，慢性梗死灶的SI低于正常心肌。使用钆-DTPA多聚赖氨酸时，在心肌梗死的急性和亚急性阶段可识别出三个区域，但在慢性阶段，图像显示为两个区域。在急性和亚急性梗死中，钆-DTPA多聚赖氨酸在梗死周边区产生的增强（超过60分钟）比正常或梗死心肌更大。在慢性梗死中，钆-DTPA多聚赖氨酸对中央梗死区的SI没有明显影响。总体而言，它没有引起明显的血流动力学效应。使用钆-DTPA多聚赖氨酸进行MR成像在心肌梗死中产生了不同的组织增强，这根据梗死的时间而有所不同。
