Lim T H, Lee D H, Kim Y H, Park S W, Park P H, Seo D M, Kim S T, Lee T K, Mun C W
Department of Radiology, Asan Medical Center, SongPa-Ku, Seoul, Korea.
Radiology. 1993 Dec;189(3):765-8. doi: 10.1148/radiology.189.3.7694313.
To assess the capability of gadolinium polylysine-enhanced cardiac magnetic resonance (MR) imaging in depicting normal and ischemic myocardium during occlusion and reperfusion of the left anterior descending artery.
Contrast-enhanced MR images were obtained in 18 cats during 90 minutes each of occlusion and reperfusion. The change in signal intensity (SI) was compared among normal myocardium and central and peripheral ischemic zones. Results were compared with those of 2,3,5-triphenyltetrazolium chloride staining.
During occlusion, the ischemic zone lacked enhancement while normal myocardium had gradual enhancement. During reperfusion, the ischemic zone had strong enhancement. In cats with large infarction, the central and peripheral ischemic zones had intermediate and high SI, respectively; in cats with focal or no infarction, the entire ischemic zone had high SI.
Occlusive and reperfused myocardial infarction can be detected at gadolinium polylysine-enhanced MR imaging by means of differential SI changes in normal myocardium and central and peripheral ischemic zones.
评估钆聚赖氨酸增强心脏磁共振成像在描绘左前降支动脉闭塞和再灌注期间正常心肌和缺血心肌方面的能力。
在18只猫的闭塞和再灌注各90分钟期间获取对比增强磁共振图像。比较正常心肌以及中央和外周缺血区的信号强度（SI）变化。将结果与2,3,5 - 三苯基氯化四氮唑染色的结果进行比较。
在闭塞期间，缺血区无强化，而正常心肌有逐渐强化。在再灌注期间，缺血区有强烈强化。在有大面积梗死的猫中，中央和外周缺血区的SI分别为中等和高；在有局灶性梗死或无梗死的猫中，整个缺血区的SI均为高。
通过正常心肌以及中央和外周缺血区不同的SI变化，钆聚赖氨酸增强磁共振成像能够检测出闭塞性和再灌注性心肌梗死。
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