Gean-Marton A D, Vezina L G, Marton K I, Stimac G K, Peyster R G, Taveras J M, Davis K R
Division of Neuroradiology, Massachusetts General Hospital, Boston.
Radiology. 1991 Jul;180(1):215-21. doi: 10.1148/radiology.180.1.2052698.
The authors investigated whether identification of corpus callosal (CC) involvement might increase the specificity of magnetic resonance (MR) imaging in differentiating multiple sclerosis (MS) from other periventricular white matter diseases (PWDs). They prospectively evaluated 42 patients with MS and 127 control patients with other PWDs. Ninety-three percent of the MS patients demonstrated confluent and/or focal lesions involving the callosal-septal interface (CSI). These lesions characteristically involved the inferior aspect of the callosum and radiated from the ventricular surface into the overlying callosum. CSI lesions were optimally demonstrated on sagittal long repetition time (TR)/short echo time (TE) images and frequently (45% of cases) went undetected on axial images. Only 2.4% of the control patients had lesions of the CC. The authors conclude that midsagittal long TR/short TE images are highly sensitive and specific for MS and that callosal involvement in MS is more common than previously reported.
作者们研究了胼胝体（CC）受累的识别是否会提高磁共振（MR）成像在区分多发性硬化症（MS）与其他脑室周围白质疾病（PWD）时的特异性。他们前瞻性地评估了42例MS患者和127例患有其他PWD的对照患者。93%的MS患者表现出累及胼胝体-隔界面（CSI）的融合性和/或局灶性病变。这些病变典型地累及胼胝体的下方，并从脑室表面向上延伸至上方的胼胝体。CSI病变在矢状面长重复时间（TR）/短回波时间（TE）图像上显示最佳，而在轴位图像上经常（45%的病例）未被检测到。只有2.4%的对照患者有CC病变。作者得出结论，矢状面长TR/短TE图像对MS具有高度敏感性和特异性，并且MS中胼胝体受累比以前报道的更为常见。
