Clement O, Frija G, Chambon C, Schouman-Clayes E, Mosnier J F, Poupon M F, Balkau B
Department of Radiology, Hôpital Laennec, Université de Paris, France.
Radiology. 1991 Jul;180(1):31-6. doi: 10.1148/radiology.180.1.2052718.
The influence of cirrhosis on superparamagnetic iron oxide (SPIO)-enhanced magnetic resonance (MR) imaging of the liver was studied in 31 rats. Experimental models included carbon tetrachloride-induced cirrhosis and liver engrafting of rhabdomyosarcoma S4T cells. Hepatic uptake of SPIO measured with relaxometry decreased dramatically with histologic grade, while splenic uptake increased; the same results were achieved by calculating K values. Imaging of 13 tumorous cirrhotic rats confirmed these results by showing a muted decrease in liver signal intensity on spin-echo images after injection of SPIO. Nevertheless, all intrahepatic tumors could be visualized, as confirmed by postmortem examination. On gradient-echo images, postinjection contrast between the tumor and the liver was not affected by cirrhosis. Thus, despite strong impairment of hepatic uptake in cirrhosis, the diagnostic efficacy of MR imaging with SPIO did not seem to be significantly affected.
在31只大鼠中研究了肝硬化对超顺磁性氧化铁（SPIO）增强肝脏磁共振（MR）成像的影响。实验模型包括四氯化碳诱导的肝硬化和横纹肌肉瘤S4T细胞肝移植。通过弛豫测量法测得的肝脏对SPIO的摄取随组织学分级显著降低，而脾脏摄取增加；通过计算K值也得到了相同结果。对13只肿瘤性肝硬化大鼠的成像通过在注射SPIO后自旋回波图像上显示肝脏信号强度的减弱证实了这些结果。然而，所有肝内肿瘤均可通过尸检得以显示。在梯度回波图像上，注射后肿瘤与肝脏之间的对比度不受肝硬化影响。因此，尽管肝硬化时肝脏摄取受到严重损害，但SPIO增强MR成像的诊断效能似乎并未受到显著影响。
