Mossa B, Torcia F, Avenoso F, Tucci S, Marziani R
Department of Gynaecology, Perinatology and Child Health, Sapienza University, Rome, Italy.
Eur J Gynaecol Oncol. 2010;31(2):165-8.
To evaluate the occurrence of endometrial polyp malignancy in pre- and postmenopausal women with or without symptoms.
A retrospective study was performed on 351 patients with endometrial polyps diagnosed by hysteroscopy.
Histological findings of biopsies obtained by operative hysteroscopy confirmed the presence of a simple endometrial polyp in 179 cases, polyps with typical simple hyperplasia in 42 cases, polyps with typical complex hyperplasia in 24 cases, polyps with atypical complex hyperplasia in three cases; carcinomatous polyps in seven cases; atrophic polyps in 17 cases; functional polyps in 56 cases; and inadequate sample in 23 cases. All seven patients with adenocarcinoma were symptomatic; six out of seven patients with adenocarcinoma were in postmenopause and one was in premenopause. The association between menopausal status and symptoms, and the presence of a malignant lesion was statistically significant (p < 0.001).
This study revealed that prevalence of endometrial polyp malignant transformation was < or = 2.84% in postmenopausal and symptomatic patients.
评估有症状或无症状的绝经前和绝经后女性子宫内膜息肉恶变的发生率。
对351例经宫腔镜诊断为子宫内膜息肉的患者进行回顾性研究。
经手术宫腔镜活检的组织学结果证实，179例为单纯性子宫内膜息肉，42例为伴有典型单纯性增生的息肉，24例为伴有典型复杂性增生的息肉，3例为伴有非典型复杂性增生的息肉；7例为癌性息肉；17例为萎缩性息肉；56例为功能性息肉；23例样本不足。所有7例腺癌患者均有症状；7例腺癌患者中有6例处于绝经后，1例处于绝经前。绝经状态与症状以及恶性病变的存在之间的关联具有统计学意义（p < 0.001）。
本研究表明，绝经后有症状患者子宫内膜息肉恶变的发生率≤2.84%。
