Zozulińska Dorota
Klinika Chorób Wewnetrznych i Diabetologii, Akademia Medyczna, Poznań.
Kardiol Pol. 2006 Oct;64(10 Suppl 6):S567-71.
This paper presents an opinion about disturbances of lipids characteristic of impaired metabolism induced by obesity and insulin resistance. In these conditions dyslipidaemia, especially with hyperglycaemia, plays a key role in the aetiopathogenesis of cardiovascular diseases. Atherogenic dyslipidaemia consists of a reduction in HDL cholesterol, elevations of triglycerides and apo B and arising of small and dense LDL and HDL particles modified by oxidation and glycation. The fundamental approach is weight reduction, increased physical activity and drug treatment leading to regression of these disturbances.
本文提出了关于肥胖和胰岛素抵抗所致代谢受损特征性脂质紊乱的一种观点。在这些情况下,血脂异常,尤其是合并高血糖时,在心血管疾病的病因发病机制中起关键作用。致动脉粥样硬化性血脂异常包括高密度脂蛋白胆固醇降低、甘油三酯和载脂蛋白B升高,以及出现经氧化和糖基化修饰的小而密低密度脂蛋白和高密度脂蛋白颗粒。基本方法是减轻体重、增加体力活动以及进行药物治疗,以促使这些紊乱情况得到改善。