Drelicharz L, Mikita J, Chabielska E, Chłopicki S
Zakład Farmakologii Doświadczalnej, Katedra Farmakologii, Collegium Medicum, Uniwersytet Jagielloński, Kraków.
Kardiol Pol. 2005 Oct;63(4 Suppl 2):S409-19.
Aldosterone is the main hormone regulating the water and electrolyte balance of the organism. It is produced and secreted by zona glomerulosa of the adrenal gland cortex, cardiomyocytes as well as by cells of the blood vessel wall. The article is the review of contemporary knowledge of the role of aldosterone in physiology and pathophysiology of cardiovascular system. The authors describe the nuclear and membrane mechanisms of endothelial action of aldosterone, especially their role in the development of cardiovascular system pathologies. New therapeutic indications for aldosterone receptor antagonists are also discussed.
醛固酮是调节机体水和电解质平衡的主要激素。它由肾上腺皮质球状带、心肌细胞以及血管壁细胞产生并分泌。本文是对醛固酮在心血管系统生理和病理生理中作用的当代知识综述。作者描述了醛固酮内皮作用的核机制和膜机制，尤其是它们在心血管系统疾病发展中的作用。还讨论了醛固酮受体拮抗剂的新治疗适应证。
