Oberleithner Hans
Institut für Physiologie II, University of Münster, Robert-Koch-Strasse 27b, 48149 Münster, Germany.
Pflugers Arch. 2007 May;454(2):187-93. doi: 10.1007/s00424-007-0205-7. Epub 2007 Feb 7.
Fluid and electrolyte balance in the human organism is controlled by aldosterone, a mineralocorticoid hormone of the suprarenal glands. The major target cells are localized in the kidney where the hormone controls transepithelial salt transport. Over the past few years, evidence has been accumulated that cells of the cardiovascular system are also targeted by the hormone. As an example, endothelial cells resemble similar mechanisms triggered by aldosterone as shown for the kidney. Although the pathological alterations induced by aldosterone excess are obvious, the physiological changes are largely unknown. On the basis of recent experiments, using atomic force microscopy as an imaging tool and a mechanical sensor, I present a hypothesis on the physiological role of aldosterone in endothelial function and its potential implications in the control of blood pressure.
人体机体中的体液和电解质平衡由醛固酮控制，醛固酮是肾上腺分泌的一种盐皮质激素。主要靶细胞位于肾脏，该激素在肾脏中控制跨上皮盐转运。在过去几年中，已有证据表明心血管系统的细胞也是该激素的作用靶点。例如，内皮细胞类似于醛固酮在肾脏中引发的类似机制。尽管醛固酮过量引起的病理改变很明显，但其生理变化在很大程度上尚不清楚。基于最近的实验，使用原子力显微镜作为成像工具和机械传感器，我提出了一个关于醛固酮在内皮功能中的生理作用及其在血压控制中的潜在影响的假说。
