Gottlieb C, Andersson E, Fried G
Department of Obstetrics and Gynecology, Karolinska Hospital, Stockholm, Sweden.
Prostaglandins. 1991 Jun;41(6):607-13. doi: 10.1016/0090-6980(91)90065-n.
Human semen contains high amounts of different prostaglandins of which the quantitatively dominating compounds are 19-hydroxy PGE and 19-hydroxy PGF. The effect of PGE and PGF on the contractility of the human uterus is well known whereas the corresponding 19-hydroxy derivatives have not previously been examined in detail. In the present investigation 19-hydroxy PGE1 was shown to dose-dependently decrease the frequency and the amplitude of the contractions in human myometrial tissue in vitro. The effect of seminal 19-hydroxy prostaglandins may thus be of importance for sperm transport through the female genital tract.
人类精液中含有大量不同的前列腺素，其中含量占主导的化合物是19-羟基前列地尔（PGE）和19-羟基前列环素（PGF）。PGE和PGF对人类子宫收缩性的影响是众所周知的，而相应的19-羟基衍生物此前尚未得到详细研究。在本研究中，19-羟基前列地尔1被证明在体外能剂量依赖性地降低人子宫肌层组织收缩的频率和幅度。因此，精液中19-羟基前列腺素的作用可能对精子通过女性生殖道的运输具有重要意义。
