Bacior Bogumiła, Kubinyi Aleksandra, Klecha Artur, Styczkiewicz Katarzyna, Olszanecka Agnieszka, Kawecka-Jaszcz Kalina
I Klinika Kardiologii, Collegium Medicum Uniwersytetu Jagiellońskiego, Kraków.
Kardiol Pol. 2004 Sep;61 Suppl 2:II82-8.
Autonomic nervous system plays an important role in the pathogenesis of chronic heart failure (CHF). Increasing sympathetic nervous activity and decreasing parasymphatetic activity has been observed in the course of CHF. Physical training modulates the activity of the autonomic nervous system and restores the sympathovagal balance, hence it may improve the prognosis in CHF.
The aim of the study was to assess the influence of a 6-month physical training in patients with chronic ischaemic heart failure on the indices of autonomic nervous system activity--blood pressure and heart rate variability.
The study group consisted of 42 patients with CHF, NYHA class II and III. Patients were divided into three groups: Group I--patients who were not trained at all, Group II--patients with interval training, Group III--patients who were trained according to model with progressive increase of workload. At baseline groups did not differ according to age, clinical parameters and biochemical parameters. In all subjects 24-hr ECG monitoring was performed (with time domain heart rate variability assessment), as well as 24-hr blood pressure monitoring to analyse blood pressure variability.
After 6 months we observed significant improvement in HRV parameters in Group III--those trained with progressive increase of workload (delta SDNN + 88.2 ms, p < 0.05). In Group II (interval training) HRV parameters remained unchanged after 6 months of training (delta SDNN + 2.5 ms, NS). Group I (without training) revealed deterioration in HRV parameters (delta SDNN--12.9 ms, p < 0.05). There were no differences in the mean blood pressure and blood pressure variability in all examined groups after 6 months of follow-up compared to baseline.
In the examined group of patients with chronic heart failure, 6 months physical training with progressive increase of workload significantly improves autonomic function assessed by means of heart rate variability.
自主神经系统在慢性心力衰竭(CHF)的发病机制中起重要作用。在CHF病程中已观察到交感神经活动增加和副交感神经活动减少。体育锻炼可调节自主神经系统的活动并恢复交感迷走平衡,因此可能改善CHF的预后。
本研究旨在评估6个月体育锻炼对慢性缺血性心力衰竭患者自主神经系统活动指标——血压和心率变异性的影响。
研究组由42例CHF患者组成,纽约心脏协会(NYHA)心功能分级为II级和III级。患者分为三组:第一组——完全未训练的患者;第二组——进行间歇训练的患者;第三组——按照工作量逐渐增加模式训练的患者。基线时,各组在年龄、临床参数和生化参数方面无差异。对所有受试者进行24小时心电图监测(进行时域心率变异性评估)以及24小时血压监测以分析血压变异性。
6个月后,我们观察到第三组(按照工作量逐渐增加模式训练的患者)的心率变异性参数有显著改善(标准差NN间期差值增加88.2毫秒,p<0.05)。第二组(间歇训练)在训练6个月后心率变异性参数保持不变(标准差NN间期差值增加2.5毫秒,无统计学意义)。第一组(未训练)的心率变异性参数恶化(标准差NN间期差值减少12.9毫秒,p<0.05)。随访6个月后,所有检查组的平均血压和血压变异性与基线相比无差异。
在本研究的慢性心力衰竭患者组中,6个月工作量逐渐增加的体育锻炼可显著改善通过心率变异性评估的自主神经功能。