Qureshi Asim, Pervez Shahid
Department of Pathology, Shaukat Khanum Cancer Hospital, Lahore.
J Pak Med Assoc. 2010 May;60(5):350-3.
To determine the scoring of Estrogen Receptor (ER) status in carcinoma breast by Allred method that is essentially bimodal and to compare the results with a conventional scoring system.
A retrospective, comparative study carried out at Aga Khan University Hospital Section of Histopathology over a period of 18 months, i.e., Jan 2005 to June 2006. Anti ER antibody (clone D07) was used for all IHC stains using envision detection system. ER stains of 860 consecutive breast cancer cases were reviewed and rescored by both conventional and Allred method of ER scoring.
Comparison of results showed that there was a substantial decrease in weak positive cases from 18% to 5% by rescoring using Allred scoring system compared to conventional scoring. The data was analyzed using chi square test.
The sensitivity and specificity of Allred method were calculated; Sensitivity of Allred method was 99.4% & Specificity of Allred method was 99.5% whereas sensitivity and specificity of conventional method was 88.0% and 84% respectively
采用本质上为双峰的奥尔雷德方法确定乳腺癌中雌激素受体（ER）状态的评分，并将结果与传统评分系统进行比较。
在阿迦汗大学医院组织病理学科室进行了一项为期18个月（即2005年1月至2006年6月）的回顾性比较研究。所有免疫组化染色均使用抗ER抗体（克隆D07）及恩vision检测系统。对860例连续乳腺癌病例的ER染色进行回顾，并采用传统和奥尔雷德ER评分方法重新评分。
结果比较显示，与传统评分相比，使用奥尔雷德评分系统重新评分后，弱阳性病例大幅减少，从18%降至5%。数据采用卡方检验进行分析。
计算了奥尔雷德方法的敏感性和特异性；奥尔雷德方法的敏感性为99.4%，特异性为99.5%，而传统方法的敏感性和特异性分别为88.0%和84%
