Ferdaus Mohammed Zubaerul, Hasan A K M Mahbub, Shekhar Hossain Uddin
Novartis Limited, Bangladesh.
J Pak Med Assoc. 2010 May;60(5):360-4.
To assess the serum lipid profile of cardiovascular disease free male and female children with beta-thalassaemia. Levels of zinc, copper and magnesium in the serum were also determined along with the Thyroid profile.
From January to December 2007, we enrolled 121 consecutive patients with beta-thalassaemia that visited The Thalassaemia Center at Dhaka Shishu (Children) Hospital, Bangladesh every month for routine examinations. Fasting blood lipid levels were measured in all participants. Zinc, Copper and Magnesium levels in serums were determined. Thyroid function was also assessed by evaluating T3, T4 and TSH levels.
Of the 121 patients, 65 were males (10.14 +/- 3.91 years) and 56 were females (9.08 +/- 4.32 years). Data analysis revealed that 2.0% males and 4.35% females had high total serum cholesterol, and 28.57% males and 21.74% females had high triglyceride levels. In addition, mean HDL-cholesterol levels were 21.14 +/- 5.82 mg/dl in males and 21.17 +/- 6.02 mg/dl in females; total-cholesterol to HDL-cholesterol ratios were 5.47 +/- 1.66 and 5.96 +/- 2.81 in males and females respectively. About 60% patients showed low serum level of Zn and Cu. Hypothyroidism was detected in 30% patients and 23% patients had abnormal experimental values of all the study parameters.
The majority of the patients had blood lipid levels (by the exception of HDL-cholesterol) within the normal range, and consequently the prevalence of lipid abnormalities was much lower as compared to the general population of the same age. Interestingly, the total-cholesterol to HDL-cholesterol ratio was high in our patients, and may underline the importance of this index for the prognosis of future cardiac events in these patients. The serum Zn and Cu levels were low in most of the patients which may cause some metabolic abnormalities in future. Most of the patients also showed hypothyroidism indicating the presence of endocrine complications.
评估无心血管疾病的β地中海贫血男女儿童的血脂谱。同时测定血清中锌、铜和镁的水平以及甲状腺功能指标。
2007年1月至12月，我们纳入了121例连续就诊于孟加拉国达卡儿童专科医院地中海贫血中心进行常规检查的β地中海贫血患者。测量了所有参与者的空腹血脂水平。测定了血清中锌、铜和镁的水平。还通过评估T3、T4和TSH水平来评估甲状腺功能。
121例患者中，65例为男性（10.14±3.91岁），56例为女性（9.08±4.32岁）。数据分析显示，2.0%的男性和4.35%的女性总血清胆固醇水平较高，28.57%的男性和21.74%的女性甘油三酯水平较高。此外，男性的平均高密度脂蛋白胆固醇水平为21.14±5.82mg/dl，女性为21.17±6.02mg/dl；男性和女性的总胆固醇与高密度脂蛋白胆固醇之比分别为5.47±1.66和5.96±2.81。约60%的患者血清锌和铜水平较低。30%的患者检测出甲状腺功能减退，23%的患者所有研究参数的实验值异常。
大多数患者的血脂水平（高密度脂蛋白胆固醇除外）在正常范围内，因此与同年龄的普通人群相比，脂质异常的患病率要低得多。有趣的是，我们的患者总胆固醇与高密度脂蛋白胆固醇之比很高，这可能突出了该指标对这些患者未来心脏事件预后的重要性。大多数患者血清锌和铜水平较低，这可能会在未来导致一些代谢异常。大多数患者还表现出甲状腺功能减退，表明存在内分泌并发症。
