King Bradley J, Furlong Teri M, McNally Gavan P
School of Psychology, The University of New South Wales, Sydney, NSW, 2052, Australia.
Behav Neurosci. 2010 Jun;124(3):423-7. doi: 10.1037/a0019540.
We studied the role of cocaine and amphetamine related transcript (CART) in regulating context induced reinstatement (renewal) of reward seeking. Rats were trained to respond for alcoholic beer in context A before extinction in context B. Rats were tested for responding in context A (ABA) and context B (ABB). Intracerebroventricular (ICV) infusions of the active fragment CART55-102 but not the inactive fragment CART1-27 before test prevented ABA renewal of extinguished responding. ICV CART55-102 had no effect on responding in the extinction context (ABB). ICV CART55-102 also altered the profile of behavioral responses observed on test in the training (ABA) but not extinction (ABB) context. These results identify a novel role for CART in preventing reinstatement of reward seeking.
我们研究了可卡因和苯丙胺相关转录物（CART）在调节情境诱导的奖赏寻求恢复（复现）中的作用。大鼠先在情境A中训练以对酒精啤酒做出反应，然后在情境B中进行消退训练。对大鼠在情境A（ABA）和情境B（ABB）中的反应进行测试。在测试前，脑室内（ICV）注射活性片段CART55 - 102可阻止消退反应的ABA复现，但注射无活性片段CART1 - 27则无效。脑室内注射CART55 - 102对消退情境（ABB）中的反应没有影响。脑室内注射CART55 - 102还改变了在训练情境（ABA）而非消退情境（ABB）中测试时观察到的行为反应模式。这些结果确定了CART在防止奖赏寻求恢复方面的新作用。
