Perry Christina J, McNally Gavan P
School of Psychology, The University of New South Wales, Australia.
Behav Neurosci. 2013 Aug;127(4):535-43. doi: 10.1037/a0032981.
Opioid antagonists reduce the rate of relapse to drinking in clinical trials and reduce reinstatement in animal models of drug seeking. However, the neuroanatomical locus for this effect remains poorly understood. We examined the role of nucleus accumbens shell (AcbSh) μ-opioid receptors in two different forms of recovery of alcoholic beer seeking. Rats were trained to nosepoke for alcoholic beer in a distinctive context and this response was then extinguished. Response recovery was produced via renewal (context-induced reinstatement) (Experiment 1) or primed reinstatement (Experiment 2). Rats received microinjections of the μ-opioid receptor antagonist CTAP before these tests. AcbSh microinfusion of 2.5 μg CTAP attenuated the ABA renewal of alcoholic beer seeking in a neuroanatomically specific manner. In contrast, AcbSh microinfusion of 2.5 μg or 5 μg CTAP had no effect on the primed reinstatement of alcoholic beer seeking. These findings indicate a role for AcbSh μ-opioid receptors in renewal of alcoholic beer seeking and suggest that there are dissociable ventral striatal substrates for different forms of recovery of extinguished alcoholic beer seeking.
在临床试验中，阿片类拮抗剂可降低饮酒复发率，并在药物寻求的动物模型中减少复吸。然而，这种作用的神经解剖学位点仍知之甚少。我们研究了伏隔核壳（AcbSh）μ-阿片受体在两种不同形式的寻求酒精啤酒恢复中的作用。大鼠在一个独特的环境中接受训练，通过鼻触来获取酒精啤酒，然后这种反应被消退。反应恢复通过重新激发（情境诱导的复吸）（实验1）或启动复吸（实验2）产生。在这些测试之前，大鼠接受了μ-阿片受体拮抗剂CTAP的微量注射。向AcbSh微量注射2.5μg CTAP以神经解剖学特异性方式减弱了酒精啤酒寻求的ABA重新激发。相比之下，向AcbSh微量注射2.5μg或5μg CTAP对酒精啤酒寻求的启动复吸没有影响。这些发现表明AcbShμ-阿片受体在酒精啤酒寻求的重新激发中起作用，并表明对于消退的酒精啤酒寻求的不同恢复形式存在可分离的腹侧纹状体底物。
