Instituto para La Salud de La Mujer, Guayaquil, Ecuador.
Gynecol Endocrinol. 2011 May;27(5):307-13. doi: 10.3109/09513590.2010.490614. Epub 2010 Jun 8.
Risk-benefit issues raised after the WHI have significantly increased the use of alternative treatments for the menopause. Despite this, data regarding the effect of soy isoflavones over mood and menopausal symptoms in high risk populations is still lacking.
To evaluate the effect of soy derived isoflavones over hot flushes, menopausal symptoms and mood in climacteric women with increased body mass index (BMI).
Fifty symptomatic climacteric women aged 40 to 59 with increased BMI (≥ 25) were recruited to receive oral 100 mg/day of soy derived isoflavones (Climasoy) for 3 months. Hot flushes (frequency/intensity), menopausal symptoms (Menopause Rating Scale [MRS]) and mood (Hamilton Depressive Rating Scale [HDRS]) were evaluated at baseline and at 90 days.
A total of 45 women completed the study. After 3 months of soy isoflavone supplementation hot flushes significantly decreased in percentage, number and severity (100% to 31.1%; 3.9 ± 2.3 to 0.4 ± 0.8 and 2.6 ± 0.9 to 0.4 ± 0.8, respectively, p < 0.001). MRS scores (total and for subscales) reflecting general menopausal symptoms also significantly decreased compared to baseline. Regarding mood, after three months total HDRS scores and the rate of women presenting depressed mood (scores ≥ 8) significantly decreased (16.3 ± 5.4 to 6.9 ± 5.2 and 93.3% to 28.9%, respectively, p < 0.05). There was no effect on blood pressure levels or BMI values after treatment.
In this high risk climacteric population, soy derived isoflavone treatment improved mood as well as vasomotor and general menopausal symptoms. More research is required to determine if the positive effect over mood is a direct or an indirect one through hot flush alleviation.
WHI 之后出现的风险-效益问题极大地增加了替代疗法在更年期的应用。尽管如此，关于大豆异黄酮对高危人群情绪和更年期症状的影响的数据仍然缺乏。
评估大豆异黄酮对体重指数（BMI）升高的更年期妇女热潮、更年期症状和情绪的影响。
招募了 50 名年龄在 40 至 59 岁、BMI 增加（≥25）的有症状的更年期妇女，每天口服 100 毫克大豆异黄酮（Climasoy），持续 3 个月。在基线和 90 天时评估热潮（频率/强度）、更年期症状（更年期评定量表[MRS]）和情绪（汉密尔顿抑郁评定量表[HDRS]）。
共有 45 名妇女完成了研究。大豆异黄酮补充 3 个月后，热潮的百分比、次数和严重程度均显著降低（100%降至 31.1%；3.9 ± 2.3 降至 0.4 ± 0.8，2.6 ± 0.9 降至 0.4 ± 0.8，均 P < 0.001）。反映一般更年期症状的 MRS 评分（总分和各亚量表）也与基线相比显著降低。关于情绪，3 个月后，总 HDRS 评分和出现抑郁情绪（评分≥8）的妇女比例显著降低（16.3 ± 5.4 降至 6.9 ± 5.2，93.3%降至 28.9%，均 P < 0.05）。治疗后血压水平或 BMI 值无变化。
在这种高危更年期人群中，大豆异黄酮治疗改善了情绪以及血管舒缩和一般更年期症状。需要进一步研究以确定对情绪的积极影响是直接的还是通过缓解热潮间接的。
