Department of Fundamental, Prophylactic and Clinical Sciences, Faculty of Medicine, Transilvania University of Brasov, 500019 Brașov, Romania.
Department of Medical and Surgical Specialties, Faculty of Medicine, Transylvania University of Brasov, 500019 Brașov, Romania.
Nutrients. 2024 Feb 26;16(5):649. doi: 10.3390/nu16050649.
The objective of this study was to determine the effects of royal jelly and fermented soy extracts on menopausal symptoms and on quality of life in pre- and post-menopausal women.
This prospective observational study was carried out in a Clinical Hospital of Brasov, Romania, during June 2020 and December 2021. Eighty pre- and post-menopausal women, aged between 45 and 60 years, were included in two groups. The first group (40 women) received a dietary supplement with fermented soy extract twice a day for eight weeks and the second group (40 women) received the same dietary supplement with fermented soy extracts and 1500 mg of royal jelly capsules for eight weeks. After the treatment, the MENQOL score, DASS-21 score, and the mean number and intensity of daily hot flushes were recorded and compared with baseline values.
After eight weeks of treatment, the score of the MENQOL questionnaire and all its domains' scores decreased in comparison with the baseline in both groups ( < 0.001). Also, the DASS-21 score ( < 0.001), depression score ( < 0.001), anxiety score ( < 0.001), and stress score ( < 0.001) improved. The mean number and the intensity of hot flushes decreased in both groups ( < 0.001). Comparing these variables after the treatment in both groups, we observed that the women who received dietary supplements with fermented soy extracts and royal jelly capsules recorded better scores for MENQOL (vasomotor, physical, and psychosocial domains) and a more reduced mean number of daily hot flushes.
This observational study suggests that both dietary fermented soy supplements and royal jelly capsules possess beneficial effects against menopausal symptoms, increase the quality of life in pre- and post-menopausal women, and that the effects might be significantly improved if those dietary supplements are administered in association.
本研究旨在确定蜂王浆和发酵大豆提取物对绝经前和绝经后妇女更年期症状及生活质量的影响。
本前瞻性观察研究于 2020 年 6 月至 2021 年 12 月在罗马尼亚布拉索夫临床医院进行。共纳入 80 名年龄在 45 至 60 岁之间的绝经前和绝经后妇女，分为两组。第一组（40 名妇女）每天服用两次含有发酵大豆提取物的膳食补充剂，共八周；第二组（40 名妇女）服用含有发酵大豆提取物和 1500 毫克蜂王浆胶囊的相同膳食补充剂，共八周。治疗后，记录 MENQOL 评分、DASS-21 评分以及每日潮热次数和强度的平均值，并与基线值进行比较。
治疗八周后，两组的 MENQOL 问卷评分及其所有领域的评分均较基线值下降（ < 0.001）。此外，DASS-21 评分（ < 0.001）、抑郁评分（ < 0.001）、焦虑评分（ < 0.001）和应激评分（ < 0.001）也均有所改善。两组的潮热次数和强度的平均值均减少（ < 0.001）。比较两组治疗后的这些变量，我们观察到服用含有发酵大豆提取物和蜂王浆胶囊的膳食补充剂的女性在 MENQOL（血管舒缩、身体和社会心理领域）方面的评分更好，每日潮热次数的平均值更低。
本观察性研究表明，饮食中摄入发酵大豆补充剂和蜂王浆胶囊均对更年期症状有有益影响，可提高绝经前和绝经后妇女的生活质量，如果联合使用这些膳食补充剂，效果可能会显著改善。
