Assistant Professor, Tulane University, Department of Health Systems Management, School of Public Health and Tropical Medicine, 1440 Canal Street, Suite 1900, New Orleans, LA 70112, USA.
Expert Rev Pharmacoecon Outcomes Res. 2007 Apr;7(2):187-202. doi: 10.1586/14737167.7.2.187.
In order for treatments to be effective, patients must be compliant with their medication regimens. Currently, patient compliance is seen as one of the most challenging issues in treating patients with chronic diseases. Studies in which dose frequency has been changed have been reviewed across several different diseases to examine the impact of a change in dose frequency on compliance and health outcomes, as well as efficacy and tolerability. In general, reducing dose frequency may improve medication compliance and effectiveness, and reduce adverse events, while possibly reducing healthcare costs. Suggestions for future research have been presented, including a need to measure compliance with injectable formulations and a standardized definition of compliance.
为了使治疗有效，患者必须遵守其药物治疗方案。目前，患者的依从性被视为治疗慢性病患者最具挑战性的问题之一。已经对几种不同疾病中改变剂量频率的研究进行了审查，以研究剂量频率的变化对依从性和健康结果以及疗效和耐受性的影响。一般来说，减少剂量频率可能会提高药物的依从性和效果，并减少不良反应，同时可能降低医疗保健成本。提出了对未来研究的建议，包括需要测量注射制剂的依从性和对依从性的标准化定义。
