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婴儿期人呼吸道合胞病毒耐药感染。

Palivizumab-resistant human respiratory syncytial virus infection in infancy.

机构信息

Institute of Virology, University Children's Hospital, Heinrich-Heine University, Düsseldorf, Germany.

出版信息

Clin Infect Dis. 2010 Jul 15;51(2):185-8. doi: 10.1086/653534.

DOI:10.1086/653534
PMID:20528472
Abstract

Palivizumab-resistant respiratory syncytial virus was isolated from an infant treated with palivizumab. A stable mutation at codon 276 led to a nearly complete resistance to palivizumab. Additional studies revealed a second mutation at codon 272. Further passage of the virus led to a complete loss of binding of palivizumab.

摘要

从接受帕利珠单抗治疗的婴儿中分离出对帕利珠单抗耐药的呼吸道合胞病毒。276 密码子的稳定突变导致对帕利珠单抗几乎完全耐药。进一步的研究发现 272 密码子的第二个突变。病毒的进一步传代导致与帕利珠单抗的结合完全丧失。

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