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病例报告:维生素 D 缺乏症多发性硬化症患者的股骨骨折——可预防的损伤。

A case report: femoral fracture in a multiple sclerosis patient with vitamin d deficiency--a preventable injury.

机构信息

Biomedical Engineering and Emergency Medicine, University of Virginia Health System, Charlottesville, VA, USA.

出版信息

J Environ Pathol Toxicol Oncol. 2010;29(1):3-5. doi: 10.1615/jenvironpatholtoxicoloncol.v29.i1.20.

Abstract

In this report, we describe the management of a multiple sclerosis patient with a femoral fracture who had severe vitamin D deficiency. After the patient's preoperative laboratory studies revealed a normal platelet count, the orthopedic surgeon performed an intramedullary rod fixation on the patient's left femoral fracture. After the surgery, the diagnosis of vitamin D deficiency was made by measuring the circulating serum concentration of 25-dihydroxyvita-min D (25(OH)D) via Disorin's Vitamin D immunochemiluminometric assay LIASION by LabCorp (Laboratory Corporation of America). The patient's postoperative management included the oral administration of 4000 IU of vitamin D3 in a gel-cap suspension that resulted in an elevation of the blood serum concentration of 25(OH)D to an optimal concentration of >80 nmol/L (32 ng/ml).

摘要

在本报告中,我们描述了一位多发性硬化症合并股骨骨折且严重维生素 D 缺乏症患者的治疗经过。在患者术前实验室检查显示血小板计数正常后,骨科医生对其左侧股骨骨折进行髓内棒固定。手术后,通过美国实验室公司的 Disorin 维生素 D 免疫化学发光测定法 LIASION 检测循环血清 25-羟维生素 D(25(OH)D)浓度,诊断为维生素 D 缺乏症。患者的术后治疗包括口服 4000IU 维生素 D3 凝胶胶囊,使血清 25(OH)D 浓度升高至最佳浓度>80nmol/L(32ng/ml)。

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