American University of Beirut, Faculty of Medicine, Hariri School of Nursing, Beirut, Lebanon.
American University of Beirut Medical Center, Nehme and Therese Tohme Multiple Sclerosis Center, Beirut, Lebanon.
Sci Rep. 2017 Apr 4;7:45926. doi: 10.1038/srep45926.
Multiple Sclerosis is associated with deficient serum 25 hydroxyvitamin D (25 (OH)D) level and cognitive impairment. The aim of this study is to evaluate cognitive performance in MS patients with deficient 25 (OH)D (<25 ng/ml) compared to patients with sufficient levels (>35 ng/ml), then to evaluate the change in cognitive performance after 3 months of vitamin D3 oral replacement. Eighty-eight MS patients with relapsing remitting and clinically isolated type of MS, older than 18 years treated with interferon beta were enrolled. Cognitive testing was performed at baseline and at 3 months using the Montreal Cognitive Assessment (MoCA), Stroop, Symbol Digit Modalities (SDMT) and Brief Visuospatial Memory Test (BVMT-R). Serum 25 (OH)D was measured at baseline and at the end of the study. Vitamin D3 replacement improved the MS patients' cognitive performance after 3 months on the MoCA and BVMT-Delayed Recall (DR). Sufficient serum 25 (OH)D level predicted better cognitive performance on the BVMT-DR at baseline (β: 1.74, p: <0.008) and 3 months (β: 1.93, p: <0.01) after adjusting for all measured confounding variables. Vitamin D replacement could improve cognitive performance in MS patients and make a significant difference in the patient's quality of life.
多发性硬化症与血清 25 羟维生素 D（25（OH）D）水平不足和认知障碍有关。本研究旨在评估 25（OH）D 水平不足（<25ng/ml）的 MS 患者与 25（OH）D 水平充足（>35ng/ml）的患者的认知表现，然后评估维生素 D3 口服替代治疗 3 个月后认知表现的变化。纳入了 88 名接受干扰素β治疗的复发缓解型和临床孤立型多发性硬化症的 18 岁以上患者。使用蒙特利尔认知评估（MoCA）、Stroop、符号数字模态测验（SDMT）和简要视觉空间记忆测验（BVMT-R）在基线和 3 个月时进行认知测试。在基线和研究结束时测量血清 25（OH）D。维生素 D3 替代治疗可改善 MS 患者在 MoCA 和 BVMT-DR 延迟回忆（DR）方面的认知表现，治疗 3 个月后。充足的血清 25（OH）D 水平预测基线（β：1.74，p：<0.008）和 3 个月（β：1.93，p：<0.01）时 BVMT-DR 的认知表现更好，并调整所有测量的混杂变量。维生素 D 替代治疗可改善 MS 患者的认知表现，并显著提高患者的生活质量。
