HIV Epidemiology, INSERM CRE U 897, Institut de Santé Publique, Epidémiologie et Développement, Université Victor Segalen, Bordeaux 2, France.
Addiction. 2010 Aug;105(8):1416-21. doi: 10.1111/j.1360-0443.2010.02978.x. Epub 2010 Jun 7.
To investigate the association between alcohol use and adherence to highly active antiretroviral treatment (HAART) among human immunodeficiency virus (HIV)-infected patients in sub-Saharan Africa.
Cross-sectional survey conducted in eight adult HIV treatment centres from Benin, Côte d'Ivoire and Mali. Participants and measurements During a 4-week period, health workers administered the Alcohol Use Disorders Identification Test to HAART-treated patients and assessed treatment adherence using the AIDS Clinical Trials Group follow-up questionnaire.
A total of 2920 patients were enrolled with a median age of 38 years [interquartile range (IQR) 32-45 years] and a median duration on HAART of 3 years (IQR 1-4 years). Overall, 91.8% of patients were identified as adherent to HAART. Non-adherence was associated with current drinking [odds ratio (OR) 1.4; 95% confidence interval (CI) 1.1-2.0], hazardous drinking (OR 4.7; 95% CI 2.6-8.6) and was associated inversely with a history of counselling on adherence (OR 0.7; 95% CI 0.5-0.9).
Alcohol consumption and hazardous drinking is associated with non-adherence to HAART among HIV-infected patients from West Africa. Adult HIV care programmes should integrate programmes to reduce hazardous and harmful drinking.
调查在撒哈拉以南非洲地区，艾滋病毒（HIV）感染者中，饮酒与高效抗逆转录病毒治疗（HAART）依从性之间的关联。
在贝宁、科特迪瓦和马里的 8 个成人 HIV 治疗中心进行的横断面调查。
在 4 周的时间内，卫生工作者对接受 HAART 治疗的患者进行了酒精使用障碍识别测试，并使用艾滋病临床试验组随访问卷评估了治疗依从性。
共纳入 2920 名患者，中位年龄为 38 岁[四分位间距（IQR）32-45 岁]，HAART 治疗中位时间为 3 年（IQR 1-4 年）。总体而言，91.8%的患者被认为对 HAART 依从。目前饮酒[比值比（OR）1.4；95%置信区间（CI）1.1-2.0]、危险饮酒（OR 4.7；95% CI 2.6-8.6）与不依从相关，而与依从性咨询史呈负相关（OR 0.7；95% CI 0.5-0.9）。
在来自西非的 HIV 感染者中，饮酒和危险饮酒与 HAART 不依从有关。成人 HIV 护理计划应纳入减少危险和有害饮酒的方案。
