Spets-Happonen S, Luoma H, Forss H, Kentala J, Alaluusua S, Luoma A R, Grönroos L, Syväoja S, Tapaninen H, Happonen P
Department of Preventive Dentistry and Cariology, University of Kuopio, Finland.
Scand J Dent Res. 1991 Apr;99(2):130-8. doi: 10.1111/j.1600-0722.1991.tb01875.x.
In order to find out if it is possible to prevent caries and gingivitis by periodical use of chlorhexidine-fluoride mouthrinses with or without strontium, and to find out what effects they have on salivary mutans streptococci and lactobacilli counts, a total of 243 schoolchildren aged 11 yr with high DMFS scores were randomly divided into four groups. One group (C) served as a basic control. Subjects in the second group (CXF) rinsed their mouths twice a day every third week with a rinsing solution containing 0.05% chlorhexidine gluconate and 0.04% NaF. In the third group (CXFS) the rinsing solution contained 500 ppm Sr during the first and second year and 15 ppm during the last 6 months, in addition to chlorhexidine and fluoride. In the fourth group (CX) the solution contained only 0.05% chlorhexidine gluconate. All the rinsing solutions had pH 5.8 buffered with succinic acid-NaOH buffer. After 2 yr and 9 months, the mean DMFS (SD) increments in the C, CXF, CXFS, and CX groups were 3.8 (5.7), 2.5 (3.2), 3.5 (4.8), and 3.4 (5.5), respectively. The percentage of subjects with bleeding gingival units had decreased from initial to final values as follows: C, 81-38; CXF, 88-42; CXFS, 89-56; CX, 89-37. The number of lactobacilli and mutans streptococci in saliva remained virtually unchanged throughout the study. For caries increment and gingival bleeding, the differences between groups were not statistically significant. The chlorhexidine-fluoride combination tended to prevent caries, but the effect on gingival bleeding and salivary counts of mutans streptococci and lactobacilli was negligible.
为了确定定期使用含或不含锶的洗必泰 - 氟化物漱口水是否有可能预防龋齿和牙龈炎，并了解它们对唾液中变形链球菌和乳酸杆菌数量有何影响，共有243名11岁且DMFS评分较高的学童被随机分为四组。一组（C组）作为基础对照组。第二组（CXF组）的受试者每三周每天用含有0.05%葡萄糖酸洗必泰和0.04%氟化钠的漱口水漱口两次。第三组（CXFS组）在第一年和第二年，漱口水除了含有洗必泰和氟化物外，还含有500 ppm的锶，在最后6个月含有15 ppm的锶。第四组（CX组）的漱口水仅含有0.05%葡萄糖酸洗必泰。所有漱口水的pH值均用琥珀酸 - 氢氧化钠缓冲液调节至5.8。2年9个月后，C组、CXF组、CXFS组和CX组的平均DMFS（标准差）增量分别为3.8（5.7）、2.5（3.2）、3.5（4.8）和3.4（5.5）。牙龈出血单位的受试者百分比从初始值到最终值的下降情况如下：C组，81% - 38%；CXF组，88% - 42%；CXFS组，89% - 56%；CX组，89% - 37%。在整个研究过程中，唾液中乳酸杆菌和变形链球菌的数量基本保持不变。对于龋齿增量和牙龈出血，各组之间的差异无统计学意义。洗必泰 - 氟化物组合倾向于预防龋齿，但对牙龈出血以及唾液中变形链球菌和乳酸杆菌数量的影响可忽略不计。
