Reppas G, Nosworthy P, Hansen T, Govendir M, Malik R
Vetnostics, North Ryde, NSW, Australia.
Aust Vet J. 2010 May;88(5):197-200. doi: 10.1111/j.1751-0813.2010.00566.x.
A 1-year-old, entire male Tasmanian devil living in captivity was presented because of a nodular inguinal lesion that subsequently developed a draining sinus tract. A second, similar lesion developed later in the ipsilateral axillary region. A deep representative biopsy specimen of abnormal subcutaneous tissue showed chronic active pyogranulomatous inflammation and beaded Gram-positive and acid-fast bacilli situated in lipid vacuoles within the lesion. A rapidly growing Mycobacterium species, shown subsequently to be M. mageritense, was grown from a swab of the primary lesion. It was susceptible to tetracyclines (including doxycycline) and moxifloxacin in vitro. The lesions resolved following treatment with doxycycline monohydrate (50 mg PO once daily) and then moxifloxacin (10 mg/kg PO for 20 days). The infection probably resulted from inoculation of subcutaneous tissues by material containing this Mycobacterium following fight or bite injuries. The presentation is reminiscent of similar lesions attributable to rapidly growing mycobacterial infections of the subcutis observed in domestic cats and quolls.
一只圈养的1岁雄性袋獾被送来就诊，它腹股沟处有一个结节性病变，随后发展成了一个有排液的窦道。同侧腋窝区域后来又出现了第二个类似病变。取自异常皮下组织的一份深度代表性活检标本显示有慢性活动性脓性肉芽肿性炎症，以及位于病变内脂质空泡中的串珠状革兰氏阳性和抗酸杆菌。从原发性病变的拭子中培养出一种生长迅速的分枝杆菌，后来鉴定为马格丽特分枝杆菌。它在体外对四环素（包括强力霉素）和莫西沙星敏感。病变在接受一水合强力霉素（每日口服50毫克）治疗，随后又接受莫西沙星（每千克体重口服10毫克，持续20天）治疗后消退。感染可能是在打斗或咬伤后，含有这种分枝杆菌的物质接种到皮下组织所致。这种表现让人联想到家猫和袋鼬中观察到由皮下快速生长的分枝杆菌感染引起的类似病变。
