University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Behav Cogn Psychother. 2010 Jul;38(4):417-36. doi: 10.1017/S1352465810000275. Epub 2010 Jun 8.
Obsessive compulsive disorder (OCD) is a chronic and disabling disorder. It profoundly compromises various aspects of patients' everyday life, thus affecting their quality of life (QoL). Using generic instruments, several studies have confirmed severely impaired health-related QoL in patients diagnosed with OCD. However, there has been a dearth of research on illness-specific QoL.
The present study aimed to further investigate subjective QoL in individuals with OCD with a focus on illness-specific aspects.
To assess subjective QoL in a broad OCD sample, an internet survey was conducted with 123 participants with obsessive-compulsive symptoms. The survey comprised both a generic (WHOQOL-BREF) and a novel self-developed OCD-specific QoL measure (QoLOC). Psychopathology was determined with diagnostic standard instruments (self-report forms of: Y-BOCS, OCI-R, BDI-SF).
Regression analyses confirmed depression as the best predictor for decreased QoL. In addition, participants reported high despair resulting from OCD-related problems that differed across symptom subtypes. An exploratory factor analysis suggested four domains of OCD-specific problems tapped by the QoLOC: (1) depressiveness in association with OCD; (2) constraints in activities due to OCD symptoms or avoidance; (3) problems with partner and/or family due to OCD symptoms or avoidance; (4) self-concept/coping of own illness.
Results produced a comprehensive picture of QoL impairments and their relation to psychopathology in a representative OCD sample. Illness-specific concerns should be further addressed in QoL research in OCD because such problems are not sufficiently mirrored in generic QoL measures.
强迫症（OCD）是一种慢性且致残的疾病。它严重影响了患者日常生活的各个方面，从而影响了他们的生活质量（QoL）。使用通用工具，多项研究证实患有 OCD 的患者的健康相关 QoL 严重受损。然而，针对疾病特异性 QoL 的研究还很少。
本研究旨在进一步研究 OCD 患者的主观 QoL，并侧重于疾病特异性方面。
为了在广泛的 OCD 样本中评估主观 QoL，我们通过互联网对 123 名具有强迫症状的个体进行了调查。该调查包括通用（WHOQOL-BREF）和新开发的 OCD 特异性 QoL 测量工具（QoLOC）。使用诊断标准工具（Y-BOCS、OCI-R、BDI-SF 的自我报告形式）确定精神病理学。
回归分析证实，抑郁是 QoL 下降的最佳预测因子。此外，参与者报告了由于 OCD 相关问题而产生的高度绝望，这些问题因症状亚型而异。探索性因素分析表明，QoLOC 可反映 OCD 特异性问题的四个领域：（1）与 OCD 相关的抑郁；（2）由于 OCD 症状或回避而导致的活动受限；（3）由于 OCD 症状或回避而导致的伴侣和/或家庭问题；（4）对自身疾病的自我概念/应对。
结果描绘了代表性 OCD 样本中 QoL 受损及其与精神病理学的关系的全面情况。在 OCD 的 QoL 研究中，应该进一步解决疾病特异性问题，因为这些问题在通用 QoL 测量中没有得到充分反映。
