MMP-13 选择性异哌可他酰胺 α-亚砜羟胺类化合物。
MMP-13 selective isonipecotamide alpha-sulfone hydroxamates.
机构信息
Department of Medicinal Chemistry, Pfizer Research & Development, St. Louis, MO 63198, USA.
出版信息
Bioorg Med Chem Lett. 2010 Jun 15;20(12):3561-4. doi: 10.1016/j.bmcl.2010.04.111. Epub 2010 Apr 28.
PMID:20529685
Abstract
A series of N-aryl isonipecotamide alpha-sulfone hydroxamate derivatives has been prepared utilizing a combination of solution-phase and resin-bound library technologies to afford compounds that are potent and highly selective for MMP-13.
摘要
利用溶液相和树脂结合文库技术的组合，制备了一系列 N-芳基异哌啶甲酰胺α-亚砜羟肟酸衍生物，得到了对 MMP-13 具有高活性和高选择性的化合物。
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