MiRror：一个用于 miRNA 及其靶基因组合分析的网络工具。
MiRror: a combinatorial analysis web tool for ensembles of microRNAs and their targets.
机构信息
Department of Biological Chemistry, Sudarsky Center for Computational Biology and School of Computer Science and Engineering, Hebrew University of Jerusalem, Israel.
出版信息
Bioinformatics. 2010 Aug 1;26(15):1920-1. doi: 10.1093/bioinformatics/btq298. Epub 2010 Jun 6.
SUMMARY
The miRror application provides insights on microRNA (miRNA) regulation. It is based on the notion of a combinatorial regulation by an ensemble of miRNAs or genes. miRror integrates predictions from a dozen of miRNA resources that are based on complementary algorithms into a unified statistical framework. For miRNAs set as input, the online tool provides a ranked list of targets, based on set of resources selected by the user, according to their significance of being coordinately regulated. Symmetrically, a set of genes can be used as input to suggest a set of miRNAs. The user can restrict the analysis for the preferred tissue or cell line. miRror is suitable for analyzing results from miRNAs profiling, proteomics and gene expression arrays.
AVAILABILITY
摘要
miRror 应用程序提供了 microRNA（miRNA）调控的见解。它基于 miRNA 或基因组合调控的概念。miRror 将基于互补算法的十几个 miRNA 资源的预测整合到一个统一的统计框架中。对于输入的 miRNA 集，该在线工具根据用户选择的资源集，基于其协调调控的显著性，为目标提供了一个排名列表。对称地，一组基因可以用作输入，以建议一组 miRNA。用户可以将分析限制在首选的组织或细胞系中。miRror 适用于分析 miRNA 谱、蛋白质组学和基因表达阵列的结果。
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