Afaq Azhar, Montgomery Polly S, Scott Kristy J, Blevins Steve M, Whitsett Thomas L, Gardner Andrew W
Department of Medicine, Cardiovascular Section, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73117, USA.
Angiology. 2008 Oct-Nov;59(5):534-41. doi: 10.1177/0003319707308728. Epub 2008 Apr 2.
The purpose was to compare calf muscle hemoglobin oxygen saturation and exercise performance in hypercholesterolemic and normocholesterolemic patients with peripheral arterial disease. Hypercholesterolemic and normocholesterolemic patients had similar ankle/ brachial index (0.72 +/- 0.24 vs 0.79 +/- 0.28, [mean +/- SD]; P = .334). Hypercholesterolemic patients had shorter initial claudication distance (214 +/- 168 m vs 331 +/- 185 m, P = .026), absolute claudication distance (391 +/- 219 m vs 549 +/- 211 m, P = .035), and lower calf muscle hemoglobin oxygen saturation at the occurrence of initial claudication distance (27 +/- 21% vs 39 +/- 20%; P = .013), and absolute claudication distance (26 +/- 21% vs 36 +/- 21%; P = .021). Hypercholesterolemia is associated with shorter walking distances and calf muscle hemoglobin oxygen saturation during exercise in patients limited by intermittent claudication.
目的是比较高胆固醇血症和正常胆固醇血症的外周动脉疾病患者小腿肌肉血红蛋白氧饱和度及运动表现。高胆固醇血症和正常胆固醇血症患者的踝/臂指数相似（分别为0.72±0.24和0.79±0.28，[均值±标准差]；P = 0.334）。高胆固醇血症患者的初始跛行距离较短（214±168米对331±185米，P = 0.026）、绝对跛行距离较短（391±219米对549±211米，P = 0.035），且在初始跛行距离出现时小腿肌肉血红蛋白氧饱和度较低（27±21%对39±20%；P = 0.013），在绝对跛行距离时也是如此（26±21%对36±21%；P = 0.021）。在受间歇性跛行限制的患者中，高胆固醇血症与运动期间较短的步行距离及小腿肌肉血红蛋白氧饱和度相关。
