Department of Thoracic and Cardiovascular Surgery, University of Göttingen, Göttingen, Germany.
Anticancer Res. 2010 Apr;30(4):1347-51.
Lactate formation is up-regulated in tumorous cells by lactate dehydrogenase (LDH). High serum LDH level is linked to many malignancies with poorer survival, but tumour LDH-5 has not been well investigated in non-small cell lung cancer (NSCLC).
In 89 patients operated on for NSCLC stage I-III, the serum LDH level was assayed and immunohistochemistry for tumour LDH-5 was performed. Impact on long-term survival and correlation was analysed.
High serum LDH was associated with poorer survival (p<0.001). No correlation was revealed between serum LDH and the tumour LDH-5. Only in tumours greater than 3 cm were high tumour LDH-5 values associated with higher serum LDH values (p=0.04) and in this subgroup, high tumor LDH-5 was associated with poorer long-term survival (p=0.024).
High serum LDH has a negative impact on long-term survival in NSCLC, whereas for tumour LDH-5, this was seen only in a subgroup of patients with larger tumours.
乳酸脱氢酶（LDH）可使肿瘤细胞内的乳酸生成增加。血清 LDH 水平升高与许多恶性肿瘤患者的生存率降低有关，但肿瘤 LDH-5 在非小细胞肺癌（NSCLC）中的研究并不充分。
对 89 例行 I-III 期 NSCLC 手术的患者检测血清 LDH 水平，并进行肿瘤 LDH-5 的免疫组化检测。分析其对长期生存的影响及其相关性。
高血清 LDH 与生存率降低相关（p<0.001）。血清 LDH 与肿瘤 LDH-5 之间无相关性。仅在肿瘤大于 3cm 的患者中，高肿瘤 LDH-5 值与较高的血清 LDH 值相关（p=0.04），且在该亚组中，高肿瘤 LDH-5 与较差的长期生存相关（p=0.024）。
高血清 LDH 对 NSCLC 的长期生存有负面影响，而对于肿瘤 LDH-5，仅在肿瘤较大的患者亚组中观察到这种情况。
