与TaqMan检测法使用相关的低水平病毒血症。
Low-level viremia associated with the use of TaqMan assay.
作者信息
Szabo Susan, Moffett Lee E, Cantwell-McNelis Kelly, James Christopher W, Joseph Abraham
机构信息
HIV Community Program, Christiana Care Health System, Wilmington, DE 19899, USA.
出版信息
J Int Assoc Physicians AIDS Care (Chic). 2010 Jul-Aug;9(4):203-5. doi: 10.1177/1545109710371131. Epub 2010 Jun 7.
Poor correlation has been reported between the Roche Cobas AmpliPrep/Cobas (TaqMan) HIV-1 TaqMan assay and the Roche Cobas Amplicor HIV-1 Monitor version 1.5 Amplicor assay. We report 8 patients who experienced unexplained detectable viremia, despite exemplary medication adherence, following a change in viral quantification assay from Amplicor to TaqMan in January 2008. All patients were found to have undetectable HIV RNA by branched DNA (bDNA) assay.
据报道，罗氏Cobas AmpliPrep/Cobas（TaqMan）HIV-1 TaqMan检测法与罗氏Cobas Amplicor HIV-1 Monitor 1.5版Amplicor检测法之间的相关性较差。我们报告了8例患者，尽管他们在2008年1月将病毒定量检测方法从Amplicor改为TaqMan后，严格遵守医嘱服药，但仍出现了无法解释的可检测到的病毒血症。所有患者通过分支DNA（bDNA）检测法均未检测到HIV RNA。
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