Germeyer Ariane, Kommoss Friedrich, Strowitzki Thomas, von Wolff Michael
Abteilung für gynäkologische Endokrinologie und Reproduktionsmedizin, Universitätsfrauenklinik Heidelberg, Vossstrasse 9, Heidelberg, Germany.
Gynakol Geburtshilfliche Rundsch. 2009;49(4):331-4. doi: 10.1159/000301113. Epub 2010 May 19.
A 27-year-old Caucasian (gravida 2 para 1) presented in week 16 of her twin pregnancy with worsening of hyperandrogenic symptoms. In week 17, she developed an acute abdomen due to a twisted, incarcerated right ovary, which was surgically removed. Histological analysis revealed a diffuse steroid cell hyperplasia. Postsurgery testosterone levels fell temporarily within normal limits, diminishing the hyperandrogenic symptoms. Over time androgen levels rose again slowly above normal values with clinical worsening of hirsutism. In the 32nd week of gestation, a cesarean section of two healthy female infants was necessary due to the development of preeclampsia. An ovarian biopsy revealed again the picture of hyperreactio luteinalis. Postpartum peripheral hormone levels fell within normal limits and the hyperandrogenic symptoms subsided.
一名27岁的白种女性（孕2产1）在双胎妊娠第16周时出现雄激素过多症状加重。第17周时，她因右侧卵巢扭转、嵌顿出现急腹症，接受了手术切除。组织学分析显示为弥漫性类固醇细胞增生。术后睾酮水平暂时降至正常范围，雄激素过多症状减轻。随着时间推移，雄激素水平再次缓慢升至正常范围以上，多毛症的临床症状加重。妊娠第32周时，由于子痫前期的发展，不得不进行剖宫产，产下两名健康女婴。卵巢活检再次显示为黄素化卵泡膜细胞增生。产后外周血激素水平降至正常范围，雄激素过多症状消退。
