Department of Physiology and Functional Explorations, Farhat Hached Hospital, Sousse, Tunisia. sonia.rouatbi @ rns.tn
Respiration. 2010;80(4):301-12. doi: 10.1159/000316339. Epub 2010 Jun 9.
In North-African adults, location-specific reference values for membrane diffusion capacity (D(m)) and pulmonary capillary blood volume (V(c)) were needed.
To verify the applicability of previously published reference equations for D(m) and V(c) in North-African healthy adults (age >18 years) and to determine specific reference equations for North Africa.
The study was designed as a prospective cross-sectional study. Anthropometric data (age, height, weight and body mass index) and D(m) and V(c) were assessed in 85 healthy Tunisian adults. Univariate and multiple linear regression analyses were used to determine reference equations and to calculate the lower limit of the normal range (LLN).
The mean ages ± SD (minimum - maximum) for male and female adults were 53 ± 21 (21-85) and 42 ± 16 (18-72) years, respectively. Previously published reference equations did not reliably predict measured D(m) and V(c). The reference equation (r(2) = 47%) for D(m) was -36.16 + 45.37 × height - 0.34 × age + 0.39 × weight + 7.41 × gender (0 = female and 1 = male). To calculate the D(m) LLN subtract 24.36 from the reference value. The reference equation (r(2) = 30%) for female V(c) was 94.70 - 0.57 × age, and the reference equation (r(2) = 52%) for male V(c) was 0.82 - 0.48 × age + 52.47 × height + 0.16 × weight. To calculate the V(c) LLN subtract 28.52 and 26.54 from these reference values for females and males, respectively.
These V(c) and D(m) reference equations supplement the international World Bank of reference equations.
在北非成年人中，需要特定部位的膜弥散量（D(m)）和肺毛细血管血容量（V(c)）的参考值。
验证先前发表的北非健康成年人（年龄>18 岁）D(m)和 V(c)参考方程的适用性，并确定北非的具体参考方程。
本研究设计为前瞻性横断面研究。评估了 85 名健康突尼斯成年人的人体测量数据（年龄、身高、体重和体重指数）以及 D(m)和 V(c)。使用单变量和多元线性回归分析来确定参考方程，并计算正常范围的下限（LLN）。
男性和女性成年人的平均年龄±标准差（最小值-最大值）分别为 53±21（21-85）和 42±16（18-72）岁。先前发表的参考方程不能可靠地预测测量的 D(m)和 V(c)。D(m)的参考方程（r²=47%）为-36.16+45.37×身高-0.34×年龄+0.39×体重+7.41×性别（0=女性，1=男性）。要计算 D(m)的 LLN，从参考值中减去 24.36。女性 V(c)的参考方程（r²=30%）为 94.70-0.57×年龄，男性 V(c)的参考方程（r²=52%）为 0.82-0.48×年龄+52.47×身高+0.16×体重。要计算 V(c)的 LLN，分别从这些参考值中减去 28.52 和 26.54，以获得女性和男性的参考值。
这些 V(c)和 D(m)参考方程补充了国际世界银行的参考方程。
