Lessig Stephanie, Ubhi Kiren, Galasko Douglas, Adame Anthony, Pham Emiley, Remidios Kelly, Chang Michael, Hansen Lawrence A, Masliah Eliezer
Departments of Neurosciences, University of California, San Diego, La Jolla, California, USA.
Neuroreport. 2010 Aug 4;21(11):756-60. doi: 10.1097/WNR.0b013e32833bfb7c.
Sleep disorders are observed in Parkinson's disease, dementia with Lewy bodies, and Alzheimer's disease; however, the underlying mechanisms are unclear. Reduced hypocretin (orexin) levels are reported in Parkinson's disease and sleep disorders, including narcolepsy; however, its levels in dementia with Lewy bodies and Alzheimer's disease and its relationship with sleep disturbances in these disorders remain undetermined. We examined hypocretin levels in dementia with Lewy bodies and Alzheimer's disease cases and correlated these with sleep habits and clinical characteristics. Although limited hypocretin alterations were observed in Alzheimer's disease, we show reduced neocortical hypocretin immunoreactivity in dementia with Lewy bodies patients correlating with hypersomnolence and alpha-synuclein levels. These results suggest the involvement of hypocretin in sleep disorders in dementia with Lewy bodies.
帕金森病、路易体痴呆和阿尔茨海默病中均观察到睡眠障碍；然而，其潜在机制尚不清楚。据报道，帕金森病和包括发作性睡病在内的睡眠障碍中，下丘脑分泌素（食欲素）水平降低；然而，其在路易体痴呆和阿尔茨海默病中的水平及其与这些疾病中睡眠障碍的关系仍未确定。我们检测了路易体痴呆和阿尔茨海默病患者的下丘脑分泌素水平，并将其与睡眠习惯和临床特征进行关联。虽然在阿尔茨海默病中观察到的下丘脑分泌素变化有限，但我们发现路易体痴呆患者新皮质下丘脑分泌素免疫反应性降低，这与嗜睡和α-突触核蛋白水平相关。这些结果表明下丘脑分泌素参与了路易体痴呆的睡眠障碍。
