Department of Surgery, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong, SAR, China.
Int J Colorectal Dis. 2010 Aug;25(8):983-8. doi: 10.1007/s00384-010-0972-z. Epub 2010 Jun 8.
Laparoscopic colon resection is technically challenging, and conversion to open surgery is sometimes unavoidable. The impact of conversion may vary among different types of colorectal resection and pathology. Our present study aims at evaluating the risk factors and clinical outcomes of conversion in laparoscopic resection for right colon cancer.
Between the periods April 1992 to July 2007, 183 consecutive patients undergoing laparoscopic-assisted right colon resection for carcinoma of colon were identified from our database. Data pertaining demographic information, operative details, postoperative course, complications, length of stay, 30-day mortality, and follow-up status were analyzed.
The overall conversion rate was 12% (22 patients). Stage IV disease, tumor length >5 cm, and surgery performed in an earlier time period (before year 2002) were independent risk factors for conversion. Although the median operative time was comparable (195 vs 180 min, p = 0.074), more blood loss was recorded among the conversion group (350 vs 20 ml, p < 0.001). Conversion was also associated with higher wound infection rate (27.3% vs 5%, p = 0.002) and 30-day mortality (9.1% vs 0.62%, p = 0.039). After potential curative resection, the 5-year overall survival rate of the conversion and no conversion group was 53.8% and 72.6%, respectively (p = 0.039).
Our results showed that conversion increased the intraoperative blood loss, wound related morbidities, and the 30-day mortality. Moreover, it had negative impact on overall survival.
腹腔镜结肠切除术技术难度大,有时不可避免地需要转为开腹手术。转化的影响可能因不同类型的结直肠切除术和病理类型而异。本研究旨在评估腹腔镜右半结肠癌切除术中转化的危险因素和临床结局。
1992 年 4 月至 2007 年 7 月期间,我们从数据库中确定了 183 例连续接受腹腔镜辅助右半结肠癌切除术治疗结肠癌的患者。分析了人口统计学信息、手术细节、术后过程、并发症、住院时间、30 天死亡率和随访情况。
总转化率为 12%(22 例)。IV 期疾病、肿瘤长度>5cm 和手术时间较早(2002 年前)是转化的独立危险因素。虽然中位手术时间相似(195 分钟与 180 分钟,p=0.074),但转化组的出血量更多(350 毫升与 20 毫升,p<0.001)。转化还与更高的伤口感染率(27.3%与 5%,p=0.002)和 30 天死亡率(9.1%与 0.62%,p=0.039)相关。在潜在的根治性切除术后,转化组和未转化组的 5 年总生存率分别为 53.8%和 72.6%(p=0.039)。
我们的结果表明,转化增加了术中出血量、与伤口相关的并发症和 30 天死亡率。此外,它对总生存率有负面影响。