Institute of NeuroImmune Pharmacology, Seton Hall University, South Orange, NJ 07079, USA.
J Neuroimmune Pharmacol. 2010 Dec;5(4):566-73. doi: 10.1007/s11481-010-9221-z. Epub 2010 Jun 9.
We recently reported that six consecutive days of treatment with a moderate dose of methamphetamine (METH) induced greater behavioral sensitization in adult HIV-1 transgenic (HIV-1 Tg) rats than in adult Fischer 344/NHsd (F344) non-transgenic, wild-type control animals. In the present study, we evaluated the effects of a moderate dose of METH on the brains of adolescent versus adult HIV-1 Tg male rats using both behavioral (METH-induced, stereotypic head movement) and physiological (rectal body temperature) parameters. We found that both the acute and behavior-sensitizing effects of METH were greater in HIV-1 Tg rats compared with controls and also in adolescent rats compared with adult animals, regardless of HIV-1 status. We determined that acute hyperthermic effects of METH as well as tolerance to METH-induced hyperthermia were greater in HIV-1 Tg rats than in controls. Taken together, these results suggest that both the neuroadaptations seen in HIV infection and the immaturity of the adolescent brain are associated with increased sensitivity to the psychoactive and behavior-sensitizing properties of METH. Thus, HIV-infected individuals and adolescents may be more vulnerable to the development of METH abuse and dependence than non-infected individuals and adults.
我们最近报道称，连续 6 天给予中等剂量的甲基苯丙胺（METH），会导致成年 HIV-1 转基因（HIV-1 Tg）大鼠比成年 Fischer 344/NHsd（F344）非转基因野生型对照动物产生更大的行为敏化。在本研究中，我们使用行为（METH 诱导的刻板头部运动）和生理（直肠体温）参数评估了中等剂量 METH 对青少年与成年 HIV-1 Tg 雄性大鼠大脑的影响。我们发现，与对照组相比，无论是 HIV-1 状态如何，HIV-1 Tg 大鼠的急性和行为敏化效应均大于对照组，而且在青少年大鼠中也大于成年动物。我们发现，METH 的急性致热作用以及对 METH 诱导的发热的耐受性在 HIV-1 Tg 大鼠中比对照组更强。综上所述，这些结果表明，HIV 感染引起的神经适应以及青少年大脑的不成熟与对 METH 的精神活性和行为敏化特性的敏感性增加有关。因此，与未感染的个体和成年人相比，感染 HIV 的个体和青少年可能更容易发展出对 METH 的滥用和依赖。
