皮肤骨肉瘤。
Osteosarcoma of the skin.
机构信息
Department of Dermatology, Mayo Clinic, Rochester, MN 55905, USA.
出版信息
Int J Dermatol. 2010 May;49(5):532-40. doi: 10.1111/j.1365-4632.2010.04315.x.
BACKGROUND
Osteosarcoma is a common malignancy, although skin metastasis is rare. We sought to review the incidence, epidemiology, risk factors, and prognosis of osteosarcoma with skin involvement.
METHODS
We conducted a retrospective chart review that covered 30 years and involved clinic patients younger than 18 years who had cutaneous metastases of osteosarcoma. The main outcome measure was histologic documentation of both primary tumor and metastatic lesion in the skin.
RESULTS
Two patients were found to have osteosarcoma with skin involvement. No unifying factors were identified.
CONCLUSIONS
Although osteosarcoma is a common malignancy with frequent metastases, involvement of the skin is rare. Further studies to identify risk factors and subsequent prognosis are necessary. Nevertheless, unidentifiable skin lesions in a patient with a history of osteosarcoma should be investigated to rule out tumor metastasis, regardless of cancer status.
背景
骨肉瘤是一种常见的恶性肿瘤，尽管皮肤转移较为罕见。我们旨在回顾伴有皮肤累及的骨肉瘤的发病率、流行病学、危险因素和预后。
方法
我们进行了一项回顾性图表研究，涵盖了 30 年的时间，涉及年龄小于 18 岁的有骨肉瘤皮肤转移的临床患者。主要的观察指标是原发性肿瘤和皮肤转移灶的组织学记录。
结果
发现 2 例骨肉瘤合并皮肤累及的患者。未确定统一的因素。
结论
尽管骨肉瘤是一种常见的具有频繁转移的恶性肿瘤，但皮肤累及很少见。需要进一步研究以确定危险因素和随后的预后。然而，对于有骨肉瘤病史的患者，无论癌症状态如何，出现无法识别的皮肤病变都应进行调查以排除肿瘤转移。
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