伊朗东南部巴姆省学龄儿童利什曼病复发病例，1994-2006 年。

Leishmaniasis recidivans among school children in Bam, South-east Iran, 1994-2006.

机构信息

Leishmaniasis Research Center, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran.

出版信息

Int J Dermatol. 2010 May;49(5):557-61. doi: 10.1111/j.1365-4632.2010.04419.x.

DOI:10.1111/j.1365-4632.2010.04419.x

PMID:20534092

Abstract

BACKGROUND

Leishmaniasis recidivans (LR) is a rare phenomenon in the world with high morbidity in children.

METHODS

Overall 22 838 school children were examined during 1994-2006. Diagnosis was performed by combination of methods as clinical appearance, direct smears, cultures, polymerase chain reaction (PCR) and histology.

RESULTS

Ninety-eight cases were diagnosed as LR with duration of lesions varying from 2 to 8 years and diameter of lesions 1-5 cm, yellowish-brown appearance with papules around or in the scar. Most of the lesions (95%) were on the face. No amastigote was found in direct smears. Identification of nine random isolates by PCR confirmed all species to be L. tropica. Tissue sections showed typical granulomatous reactions with various inflammatory cells but no visible amastigote was seen.

CONCLUSIONS

The presence of LR as an important cause of morbidity has future implications for treatment regimens and immunoprophylaxis.

摘要

背景

利什曼病复发性（LR）是一种罕见的世界性疾病，在儿童中发病率较高。

方法

1994 年至 2006 年期间，对总计 22838 名在校儿童进行了检查。诊断采用临床外观、直接涂片、培养、聚合酶链反应（PCR）和组织学相结合的方法进行。

结果

诊断为 LR 的 98 例患者，病变持续时间为 2 至 8 年，病变直径为 1 至 5 厘米，呈黄褐色，丘疹围绕或在疤痕内。大多数病变（95%）位于面部。直接涂片未发现无鞭毛体。对 9 个随机分离株的 PCR 鉴定证实所有分离株均为 L. tropica。组织切片显示典型的肉芽肿反应，有各种炎症细胞，但未见可见的无鞭毛体。