Zanazzi M, Fatini C, Farsetti S, Rosso G, Caroti L, Sticchi E, Liotta A A, Ricci I, Mannini L, Bertoni E, Abbate R, Salvadori M
Renal Unit, Department of Medical and Surgical Critical Care, Thrombosis Center, University of Florence, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy.
Transplant Proc. 2010 May;42(4):1383-4. doi: 10.1016/j.transproceed.2010.03.113.
Renal transplant recipients (RTRs) are at increased risk of cardiovascular complications. An altered hemorheological profile may determine both cardiovascular complications and progression of renal failure in RTRs. We performed this study to evaluate the rheologic status in 239 RTRs at least 12 months after transplantation with stable and normal renal function compared with 90 control subjects. In RTRs, a significantly higher hematocrit-adjusted, but not native, whole blood viscosity was found (P < .0001). Moreover, plasma viscosity and red blood cell deformability were significantly higher in patients than in control subjects (P < .0001), whereas no difference in erythrocyte aggregation between patients and control subjects was observed (P = .5). Fibrinogen, but not hematocrit, significantly increased in RTRs (P = .001). This preliminary study provides evidence of an altered hemorheologic profile in RTRs.
肾移植受者（RTRs）发生心血管并发症的风险增加。血液流变学特征的改变可能决定了RTRs的心血管并发症和肾衰竭进展。我们进行这项研究，以评估239例移植后至少12个月且肾功能稳定正常的RTRs的血液流变学状态，并与90名对照受试者进行比较。在RTRs中，发现血细胞比容校正后的全血粘度显著升高，但未校正的全血粘度未升高（P <.0001）。此外，患者的血浆粘度和红细胞变形性显著高于对照受试者（P <.0001），而患者与对照受试者之间的红细胞聚集无差异（P =.5）。RTRs的纤维蛋白原显著增加，但血细胞比容未增加（P =.001）。这项初步研究提供了RTRs血液流变学特征改变的证据。
