Skartveit L, Spak C J, Tveit A B, Selvig K A
Department of Dental Research, School of Dentistry, University of Bergen, Norway.
Acta Odontol Scand. 1991 Apr;49(2):85-8. doi: 10.3109/00016359109005891.
The purpose of this study was to evaluate the caries-inhibitory effect of TiF4 as compared with equimolar solutions of neutral and acidified NaF. Sixty Sprague-Dawley rats were weaned 19 days after birth and given a cariogenic diet. They were randomly divided into four groups and given a 1-min topical treatment of the molar teeth on day 1 and day 17 of the experiment with the following solutions: group 1: 1% TiF4, pH 1.5; group 2: 1.3% NaF, pH 7.0; group 3: 1.3% NaF, pH 1.5; and group 4: control, distilled water. From day 2 the rats were inoculated with Streptococcus mutans twice weekly. On day 55 the rats were killed, and caries scored in accordance with Keyes. Total caries scored were (mean +/- SD): group 1, 12.7 +/- 9.5; group 2, 17.4 +/- 8.6; group 3, 14.3 +/- 9.7; and group 4, 29.5 +/- 9.0. There were significantly (p less than 0.05) reduced caries scores for total caries and for buccal + lingual and sulcal areas for all test groups as compared with the control group. Differences between control and test groups in proximal surfaces and between fluoride groups were non-significant. The results showed that the caries-inhibitory effect of TiF4 is at least as good as that of NaF in rats.
本研究的目的是评估四氟化钛（TiF4）与等摩尔浓度的中性及酸化氟化钠（NaF）溶液相比的防龋效果。60只斯普拉格-道利大鼠在出生19天后断奶，并给予致龋饮食。它们被随机分为四组，并在实验的第1天和第17天用以下溶液对磨牙进行1分钟的局部处理：第1组：1% TiF4，pH 1.5；第2组：1.3% NaF，pH 7.0；第3组：1.3% NaF，pH 1.5；第4组：对照组，蒸馏水。从第2天起，每周给大鼠接种变形链球菌两次。在第55天处死大鼠，并根据凯斯标准对龋齿进行评分。总龋齿评分（平均值±标准差）为：第1组，12.7±9.5；第2组，17.4±8.6；第3组，14.3±9.7；第4组，29.5±9.0。与对照组相比，所有试验组的总龋齿以及颊面+舌面和龈沟区域的龋齿评分均显著降低（p<0.05）。对照组与试验组在邻面的差异以及氟化物组之间的差异均无统计学意义。结果表明，在大鼠中，TiF4的防龋效果至少与NaF一样好。
