Lindström S, Mazières L
Department of Physiology, University of Gothenburg, Sweden.
Acta Physiol Scand. 1991 Jan;141(1):1-10. doi: 10.1111/j.1748-1716.1991.tb09037.x.
The effect of menthol on the urinary bladder cooling reflex was studied in alpha-chloralose-anaesthetized cats. The cooling reflex was elicited by bladder or urethral instillations of cold saline and monitored by multiunit recordings from efferent and afferent pelvic nerve filaments. The bladder cooling reflex was greatly exaggerated by intraluminal exposure of the bladder or the urethra to a 0.6 mM solution of menthol. The effect occurred without a sensitizing effect on bladder mechanoreceptors. It could be described as a shift of the temperature-response curve for the cooling reflex towards higher temperatures. This change resembles the effect of menthol on cutaneous cold receptors. It is proposed that the bladder cooling reflex originates from cold receptors in the bladder and urethral walls.
在α-氯醛糖麻醉的猫身上研究了薄荷醇对膀胱冷却反射的影响。通过向膀胱或尿道灌注冷盐水来引发冷却反射，并通过传出和传入盆神经纤维的多单位记录进行监测。膀胱或尿道腔内暴露于0.6 mM薄荷醇溶液会极大地增强膀胱冷却反射。该效应在对膀胱机械感受器无致敏作用的情况下发生。它可被描述为冷却反射的温度反应曲线向更高温度的偏移。这种变化类似于薄荷醇对皮肤冷感受器的作用。有人提出，膀胱冷却反射起源于膀胱和尿道壁中的冷感受器。
