Comprehensive Breast Center & Medical Oncology, Rush University Medical Center, Chicago, IL 60612, USA.
Semin Oncol. 2011 Jun;38 Suppl 2:S11-6. doi: 10.1053/j.seminoncol.2011.04.005.
Many cytotoxic therapies are available for patients with metastatic breast cancer, but response rates are low and acquired or de novo resistance is virtually universal. Among the agents that are used in the treatment of pretreated metastatic breast cancer are vinorelbine, gemcitabine, nab-paclitaxel, pemetrexed, platinum salts (eg, cisplatin, carboplatin), pegylated liposomal doxorubicin, etoposide, and irinotecan. Therapies that improve overall survival in patients with anthracycline- and taxane-resistant metastatic breast cancer are needed.
许多细胞毒性疗法可用于转移性乳腺癌患者，但应答率低，且获得性或新发耐药几乎普遍存在。在用于治疗预处理转移性乳腺癌的药物中，包括长春瑞滨、吉西他滨、白蛋白结合型紫杉醇、培美曲塞、铂盐（如顺铂、卡铂）、多柔比星脂质体、依托泊苷和伊立替康。需要有改善蒽环类和紫杉烷类耐药转移性乳腺癌患者总生存期的治疗方法。
