NIHR Biomedical Research Centre in Ageing-Cardiovascular Theme, Newcastle University, Newcastle, UK.
QJM. 2010 Aug;103(8):589-95. doi: 10.1093/qjmed/hcq094. Epub 2010 Jun 9.
To establish the relationship between the functional impairment experienced by Chronic fatigue syndrome (CFS) patients and the symptoms frequently experienced by those with CFS; specifically cognitive impairment, fatigue and orthostatic symptoms.
Cross sectional questionnaire survey.
Specialist CFS Clinical Service.
Ninety-nine Fukuda diagnosed CFS and 64-matched controls.
Symptom and functional assessment tools completed and returned by post included; PROMIS HAQ (Patient-Reported Outcomes Measurement Information System, Health Assessment Questionnaire), CFQ (Cognitive Failures Questionnaire), FIS (Fatigue Impact Scale) and OGS (Orthostatic Grading Scale) assessment tools.
CFS patients experience greater functional impairment than controls [mean (95% CI) PROMIS HAQ scores CFS 36 (31-42) vs. controls 6 (2-10); P < 0.0001], especially in the functional domains of activities and reach. Poorer functional ability impairment is significantly associated with greater cognitive impairment (P = 0.0002, r = 0.4), fatigue (P < 0.0001, r = 0.5) and orthostatic symptoms (P < 0.0001, r = 0.6). However, only orthostatic symptoms (OGS) independently associated with functional impairment (beta = 0.4, P = 0.01).
Treatment of orthostatic symptoms in CFS has the potential to improve functional capacity and so improve quality of life.
确定慢性疲劳综合征（CFS）患者的功能障碍与 CFS 患者常经历的症状（认知障碍、疲劳和体位症状）之间的关系。
横断面问卷调查。
慢性疲劳综合征临床专科服务处。
99 名福冈诊断的 CFS 患者和 64 名匹配的对照者。
通过邮寄方式完成并返回的症状和功能评估工具包括：PROMIS HAQ（患者报告结果测量信息系统健康评估问卷）、CFQ（认知失败问卷）、FIS（疲劳影响量表）和 OGS（体位分级量表）评估工具。
CFS 患者的功能障碍比对照组更严重[平均（95%CI）PROMIS HAQ 评分 CFS 为 36（31-42），对照组为 6（2-10）；P<0.0001]，特别是在活动和伸手的功能领域。较差的功能障碍与认知障碍（P=0.0002，r=0.4）、疲劳（P<0.0001，r=0.5）和体位症状（P<0.0001，r=0.6）显著相关。然而，只有体位症状（OGS）与功能障碍独立相关（β=0.4，P=0.01）。
治疗 CFS 的体位症状有可能改善功能能力，从而提高生活质量。
